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Impact of Pulmonary Venous Inflow on Cardiac Flow Simulations: Comparison with In Vivo 4D Flow MRI
Linköping University, Department of Medical and Health Sciences, Division of Cardiovascular Medicine. Linköping University, Faculty of Medicine and Health Sciences. Linköping University, Center for Medical Image Science and Visualization (CMIV).ORCID iD: 0000-0003-1942-7699
Linköping University, Department of Medical and Health Sciences, Division of Cardiovascular Medicine. Linköping University, Center for Medical Image Science and Visualization (CMIV). Linköping University, Faculty of Medicine and Health Sciences.ORCID iD: 0000-0002-3182-1333
Linköping University, Department of Medical and Health Sciences, Division of Radiological Sciences. Linköping University, Faculty of Medicine and Health Sciences. Linköping University, Center for Medical Image Science and Visualization (CMIV).
Linköping University, Department of Management and Engineering, Applied Thermodynamics and Fluid Mechanics. Linköping University, Faculty of Science & Engineering. Linköping University, Center for Medical Image Science and Visualization (CMIV).ORCID iD: 0000-0001-5526-2399
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2019 (English)In: Annals of Biomedical Engineering, ISSN 0090-6964, E-ISSN 1573-9686, Vol. 47, no 2, p. 413-424Article in journal (Refereed) Published
Abstract [en]

Blood flow simulations are making their way into the clinic, and much attention is given to estimation of fractional flow reserve in coronary arteries. Intracardiac blood flow simulations also show promising results, and here the flow field is expected to depend on the pulmonary venous (PV) flow rates. In the absence of in vivo measurements, the distribution of the flow from the individual PVs is often unknown and typically assumed. Here, we performed intracardiac blood flow simulations based on time-resolved computed tomography on three patients, and investigated the effect of the distribution of PV flow rate on the flow field in the left atrium and ventricle. A design-of-experiment approach was used, where PV flow rates were varied in a systematic manner. In total 20 different simulations were performed per patient, and compared to in vivo 4D flow MRI measurements. Results were quantified by kinetic energy, mitral valve velocity profiles and root-mean-square errors of velocity. While large differences in atrial flow were found for varying PV inflow distributions, the effect on ventricular flow was negligible, due to a regularizing effect by mitral valve. Equal flow rate through all PVs most closely resembled in vivo measurements and is recommended in the absence of a priori knowledge.

Place, publisher, year, edition, pages
Springer-Verlag New York, 2019. Vol. 47, no 2, p. 413-424
Keywords [en]
Sensitivity analysis, Design-of-experiments, Computational fluid dynamics, In vivo measurements
National Category
Medical Image Processing Fluid Mechanics and Acoustics
Identifiers
URN: urn:nbn:se:liu:diva-153252DOI: 10.1007/s10439-018-02153-5ISI: 000456383600007PubMedID: 30362080Scopus ID: 2-s2.0-85055724908OAI: oai:DiVA.org:liu-153252DiVA, id: diva2:1268514
Funder
Knut and Alice Wallenberg FoundationAvailable from: 2018-12-06 Created: 2018-12-06 Last updated: 2019-03-22Bibliographically approved

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Lantz, JonasGupta, VikasHenriksson, LilianKarlsson, MattsPersson, AndersCarlhäll, Carl-JohanEbbers, Tino

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Lantz, JonasGupta, VikasHenriksson, LilianKarlsson, MattsPersson, AndersCarlhäll, Carl-JohanEbbers, Tino
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Division of Cardiovascular MedicineFaculty of Medicine and Health SciencesCenter for Medical Image Science and Visualization (CMIV)Division of Radiological SciencesApplied Thermodynamics and Fluid MechanicsFaculty of Science & EngineeringDepartment of Radiology in LinköpingDepartment of Clinical Physiology in Linköping
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Annals of Biomedical Engineering
Medical Image ProcessingFluid Mechanics and Acoustics

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