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Cardiovascular risk factors in non-alcoholic fatty liver disease
Karolinska Univ Hosp, Sweden; Karolinska Inst, Sweden.
Linköping University, Department of Medical and Health Sciences, Division of Cardiovascular Medicine. Linköping University, Faculty of Medicine and Health Sciences. Region Östergötland, Heart and Medicine Center, Department of Gastroentorology.
Linköping University, Department of Medical and Health Sciences, Division of Cardiovascular Medicine. Linköping University, Faculty of Medicine and Health Sciences. Region Östergötland, Heart and Medicine Center, Department of Gastroentorology.ORCID iD: 0000-0002-5590-8601
Karolinska Inst, Sweden.
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2019 (English)In: Liver international (Print), ISSN 1478-3223, E-ISSN 1478-3231, Vol. 39, no 1, p. 197-204Article in journal (Refereed) Published
Abstract [en]

Background amp; Aims Patients with non-alcoholic fatty liver disease (NAFLD) are at an increased risk for cardiovascular disease (CVD). It is unclear whether histological variables may help predict CVD risk. We evaluated histology and traditional CV risk factors as predictors of CVD outcomes in a large NAFLD cohort. Methods We included 603 biopsy-proven NAFLD patients free of baseline CVD and matched these (1:10, by age, sex and municipality) to 6269 population controls. All individuals were cross-linked to national registries to ascertain incident CVD events, defined as acute ischaemic heart disease or stroke. The presence of CV risk factors and liver histology were available in NAFLD patients only. Cox regression models were used to estimate hazard ratios (HR) for incident CVD. Results During a mean follow-up of 18.6 years, 168 (28%) of NAFLD patients and 1325 (21%) of controls experienced a CVD event (HR 1.54, 95%CI 1.30-1.83). Within the NAFLD cohort, age, male sex, type 2 diabetes, smoking and triglycerides were associated with risk of CVD. Taking these CV risk factors into account, no histological parameter, including presence of NASH and fibrosis stage, were associated with incident CVD. Conclusions Patients with NAFLD are at an increased risk for CVD compared to matched controls, but histological parameters do not seem to independently predict this risk.

Place, publisher, year, edition, pages
WILEY , 2019. Vol. 39, no 1, p. 197-204
Keywords [en]
cardiovascular disease; epidemiology; fatty liver; hepatic fibrosis; non-alcoholic steatohepatitis
National Category
Rheumatology and Autoimmunity
Identifiers
URN: urn:nbn:se:liu:diva-153817DOI: 10.1111/liv.13973ISI: 000454415500021PubMedID: 30253056OAI: oai:DiVA.org:liu-153817DiVA, id: diva2:1278052
Note

Funding Agencies|Stockholm County Council; Bengt Ihre fellowship

Available from: 2019-01-11 Created: 2019-01-11 Last updated: 2020-08-14

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Division of Cardiovascular MedicineFaculty of Medicine and Health SciencesDepartment of Gastroentorology
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