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High Keratin 8/18 Ratio Predicts Aggressive Hepatocellular Cancer Phenotype
Med Univ Graz, Austria; Ctr Biomaker Res Med, Austria.
Med Univ Graz, Austria.
Med Univ Graz, Austria; Dana Farber Canc Inst, MA 02215 USA.
Med Univ Graz, Austria; Saarland Univ, Germany.
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2019 (English)In: Translational Oncology, ISSN 1944-7124, E-ISSN 1936-5233, Vol. 12, no 2, p. 256-268Article in journal (Refereed) Published
Abstract [en]

BACKGROUND amp; AIMS: Steatohepatitis (SH) and SH-associated hepatocellular carcinoma (HCC) are of considerable clinical significance. SH is morphologically characterized by steatosis, liver cell ballooning, cytoplasmic aggregates termedMallory-Denk bodies (MDBs), inflammation, and fibrosis at late stage. Disturbance of the keratin cytoskeleton and aggregation of keratins (KRTs) are essential for MDB formation. METHODS: Weanalyzed livers of aged Krt18(-/-) mice that spontaneously developed in the majority of cases SH-associated HCC independent of sex. Interestingly, the hepatic lipid profile in Krt18(-/-) mice, which accumulate KRT8, closely resembles human SH lipid profiles and shows that the excess of KRT8 over KRT18 determines the likelihood to develop SH-associated HCC linked with enhanced lipogenesis. RESULTS: Our analysis of the genetic profile of Krt18(-/-) mice with 26 human hepatoma cell lines and with data sets of amp;gt;300 patients with HCC, where Krt18(-/-) gene signatures matched human HCC. Interestingly, a high KRT8/18 ratio is associated with an aggressive HCC phenotype. CONCLUSIONS: We can prove that intermediate filaments and their binding partners are tightly linked to hepatic lipid metabolism and to hepatocarcinogenesis. We suggest KRT8/18 ratio as a novel HCC biomarker for HCC.

Place, publisher, year, edition, pages
ELSEVIER SCIENCE INC , 2019. Vol. 12, no 2, p. 256-268
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Cell and Molecular Biology
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URN: urn:nbn:se:liu:diva-154092DOI: 10.1016/j.tranon.2018.10.010ISI: 000455497000008PubMedID: 30439626OAI: oai:DiVA.org:liu-154092DiVA, id: diva2:1283669
Note

Funding Agencies|Kurt und Senta Herrmann Stiftung; Austrian Genome Programme GEN-AU; DFG [MA1316-15, MA1316-17, MA1316-19, MA1316-21, INST 268/230-1]; German Research Foundation [STR 1095/4-2]; Else Kroner Exzellenzstipendium; Innovative Medicines Initiative Joint Undertaking from the European Unions Seventh Framework Programme (FP7/2007-2013) [115234]; EFPIA companies

Available from: 2019-01-29 Created: 2019-01-29 Last updated: 2019-03-07

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