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Surgical Management of Granular Cell Tumor of the Orbit: Case Report and Literature Review
Linköping University, Department of Clinical and Experimental Medicine, Division of Surgery, Orthopedics and Oncology. Linköping University, Faculty of Medicine and Health Sciences. Region Östergötland, Anaesthetics, Operations and Specialty Surgery Center, Maxillofacial Unit.
Region Östergötland, Anaesthetics, Operations and Specialty Surgery Center, Maxillofacial Unit.
Linköping University, Department of Clinical and Experimental Medicine, Division of Surgery, Orthopedics and Oncology. Linköping University, Faculty of Medicine and Health Sciences. Region Östergötland, Anaesthetics, Operations and Specialty Surgery Center, Maxillofacial Unit.
2019 (English)In: Open Dentistry Journal, ISSN 1874-2106, E-ISSN 1874-2106, Vol. 13, p. 33-40Article in journal (Refereed) Published
Abstract [en]

Introduction: Granular Cell Tumors (GCTs) of the orbit are rare-entity soft-tissue tumors, and few reports have been published in the literature. The treatment of the choice is total excision. Early diagnosis prior to surgery is valuable for the distinction of malignant from benign tumor.

Case presentation: We report a case of a 55-year-old woman with a solitary slow-growing mass in the right orbit with the involvement of the rectus inferior muscle, and present a review of the recent literature. The lesion had a diameter of 1 cm and was noticed 2 years before the examination. Excisional biopsy confirmed the diagnosis of GCT. The tumor was resected through a retroseptal transconjunctival approach. The final histological examination revealed findings characteristic of GCT, including positive reaction for protein S-100, SOX10, and calcitonin and negative reaction for desmin, myogenin, Smooth Muscle Antigen (SMA), Melan-A, and HMB-45. There were no signs of malignancy in this sample. Disturbance of motility was not noted by the patient after surgery.

Conclusion: GCT should be included in the differential diagnosis of intraorbital lesions, particularly those that involve the orbit muscles. A biopsy is recommended before surgical resection, to exclude malignancy and prevent radical resection.

Place, publisher, year, edition, pages
Sharjah, United Arab Emirates: Bentham Open , 2019. Vol. 13, p. 33-40
Keywords [en]
Granular cell tumor, Orbit, Protein S-100, Inferior rectus muscle, Magnetic resonance imaging, Biopsy
National Category
Surgery
Identifiers
URN: urn:nbn:se:liu:diva-154508DOI: 10.2174/1874210601913010033OAI: oai:DiVA.org:liu-154508DiVA, id: diva2:1289777
Available from: 2019-02-19 Created: 2019-02-19 Last updated: 2019-02-26Bibliographically approved

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Abtahi, JahanAjan, Aida

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