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Distinction of self-produced touch and social touch at cortical and spinal cord levels
Linköpings universitet, Institutionen för klinisk och experimentell medicin, Centrum för social och affektiv neurovetenskap. Linköpings universitet, Medicinska fakulteten.
Univ Virginia, VA 22904 USA.
Univ Virginia, VA 22904 USA.
Linköpings universitet, Institutionen för klinisk och experimentell medicin, Centrum för social och affektiv neurovetenskap. Linköpings universitet, Medicinska fakulteten. Region Östergötland, Närsjukvården i centrala Östergötland, Psykiatriska kliniken.
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2019 (Engelska)Ingår i: Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, E-ISSN 1091-6490, Vol. 116, nr 6, s. 2290-2299Artikel i tidskrift (Refereegranskat) Published
Abstract [en]

Differentiation between self-produced tactile stimuli and touch by others is necessary for social interactions and for a coherent concept of "self." The mechanisms underlying this distinction are unknown. Here, we investigated the distinction between self-and other-produced light touch in healthy volunteers using three different approaches: fMRI, behavioral testing, and somatosensory-evoked potentials (SEPs) at spinal and cortical levels. Using fMRI, we found self-other differentiation in somatosensory and sociocognitive areas. Other-touch was related to activation in several areas, including somatosensory cortex, insula, superior temporal gyrus, supramarginal gyrus, striatum, amygdala, cerebellum, and prefrontal cortex. During self-touch, we instead found deactivation in insula, anterior cingulate cortex, superior temporal gyrus, amygdala, parahippocampal gyrus, and prefrontal areas. Deactivation extended into brain areas encoding low-level sensory representations, including thalamus and brainstem. These findings were replicated in a second cohort. During self-touch, the sensorimotor cortex was functionally connected to the insula, and the threshold for detection of an additional tactile stimulus was elevated. Differential encoding of self-vs. other-touch during fMRI correlated with the individual self-concept strength. In SEP, cortical amplitudes were reduced during self-touch, while latencies at cortical and spinal levels were faster for other-touch. We thus demonstrated a robust self-other distinction in brain areas related to somatosensory, social cognitive, and interoceptive processing. Signs of this distinction were evident at the spinal cord. Our results provide a framework for future studies in autism, schizophrenia, and emotionally unstable personality disorder, conditions where symptoms include social touch avoidance and poor self-vs.-other discrimination.

Ort, förlag, år, upplaga, sidor
NATL ACAD SCIENCES , 2019. Vol. 116, nr 6, s. 2290-2299
Nyckelord [en]
sensorimotor integration; self-touch; affective touch; sensory attenuation; self-concept
Nationell ämneskategori
Neurovetenskaper
Identifikatorer
URN: urn:nbn:se:liu:diva-154553DOI: 10.1073/pnas.1816278116ISI: 000457731900074PubMedID: 30670645OAI: oai:DiVA.org:liu-154553DiVA, id: diva2:1290518
Anmärkning

Funding Agencies|ALF Grants, Region Ostergotland, Linkoping University

Tillgänglig från: 2019-02-20 Skapad: 2019-02-20 Senast uppdaterad: 2019-06-27

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Böhme, RebeccaHeilig, MarkusOlausson, Håkan
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Centrum för social och affektiv neurovetenskapMedicinska fakultetenPsykiatriska klinikenCentrum för medicinsk bildvetenskap och visualisering, CMIVNeurofysiologiska kliniken US
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Proceedings of the National Academy of Sciences of the United States of America
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