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Characterization of Clinically Relevant Strains of Extended-Spectrum beta-Lactamase-Producing Klebsiella pneumoniae Occurring in Environmental Sources in a Rural Area of China by Using Whole-Genome Sequencing
Shandong Univ, Peoples R China.
Linköpings universitet, Institutionen för klinisk och experimentell medicin, Avdelningen för mikrobiologi och molekylär medicin. Linköpings universitet, Medicinska fakulteten. Zhejiang Univ, Peoples R China.
Shandong Univ, Peoples R China.
Zhejiang Univ, Peoples R China.
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2019 (Engelska)Ingår i: Frontiers in Microbiology, ISSN 1664-302X, E-ISSN 1664-302X, Vol. 10, artikel-id 211Artikel i tidskrift (Refereegranskat) Published
Abstract [en]

Klebsiella pneumoniae is a gram-negative, opportunistic pathogen, and a common cause of healthcare-associated infections such as pneumonia, septicemia, and urinary tract infection. The purpose of this study was to survey the occurrence of and characterize K. pneumoniae in different environmental sources in a rural area of Shandong province, China. Two hundred and thirty-one samples from different environmental sources in 12 villages were screened for extended-spectrum beta-lactamase-(ESBL)-producing K. pneumoniae, and 14 (6%) samples were positive. All isolates were multidrug-resistant and a few of them belonged to clinically relevant strains which are known to cause hospital outbreaks worldwide. Serotypes, virulence genes, serum survival, and phagocytosis survival were analyzed and the results showed the presence of virulence factors associated with highly virulent clones and a high degree of phagocytosis survivability, indicating the potential virulence of these isolates. These results emphasize the need for further studies designed to elucidate the role of the environment in transmission and dissemination of ESBL-producing K. pneumoniae and the potential risk posed to human and environmental health.

Ort, förlag, år, upplaga, sidor
Frontiers Media S.A., 2019. Vol. 10, artikel-id 211
Nyckelord [en]
Klebsiella pneumoniae; extended-spectrum beta-lactamase; environment; feces; water; multilocus sequence typing; pulsed-field gel electrophoresis; whole-genome sequencing
Nationell ämneskategori
Mikrobiologi inom det medicinska området
Identifikatorer
URN: urn:nbn:se:liu:diva-154663DOI: 10.3389/fmicb.2019.00211ISI: 000458415700001OAI: oai:DiVA.org:liu-154663DiVA, id: diva2:1293217
Anmärkning

Funding Agencies|National Natural Science Foundation of China [41771499, 81361138021]; Fundamental Research Funds of Shandong University [2018JC102]; Swedish Research Council [D0879801]; Swedish Research Council Formas [2016-00640]

Tillgänglig från: 2019-03-04 Skapad: 2019-03-04 Senast uppdaterad: 2019-03-26

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Berglund, BjörnBörjesson, StefanNilsson, Lennart E
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Avdelningen för mikrobiologi och molekylär medicinMedicinska fakulteten
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Frontiers in Microbiology
Mikrobiologi inom det medicinska området

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