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Characterization of Clinically Relevant Strains of Extended-Spectrum beta-Lactamase-Producing Klebsiella pneumoniae Occurring in Environmental Sources in a Rural Area of China by Using Whole-Genome Sequencing
Shandong Univ, Peoples R China.
Linköping University, Department of Clinical and Experimental Medicine, Division of Microbiology and Molecular Medicine. Linköping University, Faculty of Medicine and Health Sciences. Zhejiang Univ, Peoples R China.
Shandong Univ, Peoples R China.
Zhejiang Univ, Peoples R China.
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2019 (English)In: Frontiers in Microbiology, ISSN 1664-302X, E-ISSN 1664-302X, Vol. 10, article id 211Article in journal (Refereed) Published
Abstract [en]

Klebsiella pneumoniae is a gram-negative, opportunistic pathogen, and a common cause of healthcare-associated infections such as pneumonia, septicemia, and urinary tract infection. The purpose of this study was to survey the occurrence of and characterize K. pneumoniae in different environmental sources in a rural area of Shandong province, China. Two hundred and thirty-one samples from different environmental sources in 12 villages were screened for extended-spectrum beta-lactamase-(ESBL)-producing K. pneumoniae, and 14 (6%) samples were positive. All isolates were multidrug-resistant and a few of them belonged to clinically relevant strains which are known to cause hospital outbreaks worldwide. Serotypes, virulence genes, serum survival, and phagocytosis survival were analyzed and the results showed the presence of virulence factors associated with highly virulent clones and a high degree of phagocytosis survivability, indicating the potential virulence of these isolates. These results emphasize the need for further studies designed to elucidate the role of the environment in transmission and dissemination of ESBL-producing K. pneumoniae and the potential risk posed to human and environmental health.

Place, publisher, year, edition, pages
Frontiers Media S.A., 2019. Vol. 10, article id 211
Keywords [en]
Klebsiella pneumoniae; extended-spectrum beta-lactamase; environment; feces; water; multilocus sequence typing; pulsed-field gel electrophoresis; whole-genome sequencing
National Category
Microbiology in the medical area
Identifiers
URN: urn:nbn:se:liu:diva-154663DOI: 10.3389/fmicb.2019.00211ISI: 000458415700001OAI: oai:DiVA.org:liu-154663DiVA, id: diva2:1293217
Note

Funding Agencies|National Natural Science Foundation of China [41771499, 81361138021]; Fundamental Research Funds of Shandong University [2018JC102]; Swedish Research Council [D0879801]; Swedish Research Council Formas [2016-00640]

Available from: 2019-03-04 Created: 2019-03-04 Last updated: 2019-03-26

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Berglund, BjörnBörjesson, StefanNilsson, Lennart E
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