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Innovative drinking water treatment techniques reduce the disinfection-induced oxidative stress and genotoxic activity
SLU, Uppsala.
Linköping University, Department of Thematic Studies, Tema Environmental Change. Linköping University, Faculty of Arts and Sciences.ORCID iD: 0000-0002-7422-0853
SLU, Uppsala, Sweden.
Norrvatten, Solna.
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2019 (English)In: Water Research, ISSN 0043-1354, E-ISSN 1879-2448, Vol. 5, p. 182-192Article in journal (Refereed) Published
Abstract [en]

Disinfection of drinking water using chlorine can lead to the formation of genotoxic by-products whenchlorine reacts with natural organic matter (NOM). A vast number of such disinfection by-products(DBPs) have been identified, making it almost impossible to routinely monitor all DBPs with chemicalanalysis. In this study, a bioanalytical approach was used, measuring oxidative stress (Nrf2 activity),genotoxicity (micronucleus test), and aryl hydrocarbon receptor (AhR) activation to evaluate an innovativewater treatment process, including suspended ion exchange, ozonation, in-line coagulation,ceramic microfiltration, and granular activated carbon. Chlorination was performed in laboratory scaleafter each step in the treatment process in order to investigate the effect of each treatment process to theformation of DBPs. Suspended ion exchange had a high capacity to remove dissolved organic carbon(DOC) and to decrease UV absorbance and Nrf2 activity in non-chlorinated water. High-dose chlorination(10 mg Cl2 L-1) of raw water caused a drastic induction of Nrf2 activity, which was decreased by 70% inwater chlorinated after suspended ion exchange. Further reduction of Nrf2 activity following chlorinationwas achieved by ozonation and the concomitant treatment steps. The ozonation treatment resulted indecreased Nrf2 activity in spite of unchanged DOC levels. However, a strong correlation was found betweenUV absorbing compounds and Nrf2 activity, demonstrating that Nrf2 inducing DBPs were formedfrom pre-cursors of a specific NOM fraction, constituted of mainly aromatic compounds. Moreover, highdosechlorination of raw water induced genotoxicity. In similarity to the DOC levels, UV absorbance andNrf2 activity, the disinfection-induced genotoxicity was also reduced by each treatment step of theinnovative water treatment technique. AhR activity was observed in the water produced by the conventionalprocess and in the raw water, but the activity was clearly decreased by the ozonation step inthe innovative water treatment process.

Place, publisher, year, edition, pages
Elsevier, 2019. Vol. 5, p. 182-192
Keywords [en]
Drinking water, disinfection byproducts, oxidative stress, Nrf2, genotoxicity
National Category
Environmental Sciences Oceanography, Hydrology and Water Resources Public Health, Global Health, Social Medicine and Epidemiology Occupational Health and Environmental Health Food Science
Identifiers
URN: urn:nbn:se:liu:diva-155072DOI: 10.1016/j.watres.2019.02.052ISI: 000464488500018PubMedID: 30849732Scopus ID: 2-s2.0-85062423705OAI: oai:DiVA.org:liu-155072DiVA, id: diva2:1295750
Funder
Swedish Research Council Formas, 2013-01077
Note

Funding agencies: Swedish Research Council Formas, Sweden [2014-1435, 2012-2124, 2018-02191, 2013-01077]; Linkoping University; SLU environmental monitoring programme on a Nontoxic environment

Available from: 2019-03-12 Created: 2019-03-12 Last updated: 2019-05-28Bibliographically approved

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Andersson, AnnaKylin, HenrikBastviken, David

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