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Brain expansion promoted by polycomb-mediated anterior enhancement of a neural stem cell proliferation program
Linköpings universitet, Medicinska fakulteten. Linköpings universitet, Institutionen för klinisk och experimentell medicin, Avdelningen för hematopoes och utvecklingsbiologi. Inst Rech Clin Montreal, Canada; Karolinska Inst, Sweden.ORCID-id: 0000-0002-2671-3645
Linköpings universitet, Institutionen för klinisk och experimentell medicin, Avdelningen för mikrobiologi och molekylär medicin. Linköpings universitet, Medicinska fakulteten.
Linköpings universitet, Institutionen för klinisk och experimentell medicin, Avdelningen för mikrobiologi och molekylär medicin. Linköpings universitet, Medicinska fakulteten. Univ Queensland, Australia.ORCID-id: 0000-0001-5095-541X
2019 (engelsk)Inngår i: PLoS biology, ISSN 1544-9173, E-ISSN 1545-7885, Vol. 17, nr 2, artikkel-id e3000163Artikkel i tidsskrift (Fagfellevurdert) Published
Abstract [en]

During central nervous system (CNS) development, genetic programs establish neural stem cells and drive both stem and daughter cell proliferation. However, the prominent anterior expansion of the CNS implies anterior-posterior (A-P) modulation of these programs. In Drosophila, a set of neural stem cell factors acts along the entire A-P axis to establish neural stem cells. Brain expansion results from enhanced stem and daughter cell proliferation, promoted by a Polycomb Group (PcG)-amp;gt;Homeobox (Hox) homeotic network. But how does PcG-amp;gt;Hox modulate neural-stem-cell-factor activity along the A-P axis? We find that the PcG-amp;gt;Hox network creates an A-P expression gradient of neural stem cell factors, thereby driving a gradient of proliferation. PcG mutants can be rescued by misexpression of the neural stem cell factors or by mutation of one single Hox gene. Hence, brain expansion results from anterior enhancement of core neural-stem-cell-factor expression, mediated by PcG repression of brain Hox expression.

sted, utgiver, år, opplag, sider
PUBLIC LIBRARY SCIENCE , 2019. Vol. 17, nr 2, artikkel-id e3000163
HSV kategori
Identifikatorer
URN: urn:nbn:se:liu:diva-155578DOI: 10.1371/journal.pbio.3000163ISI: 000460317100044PubMedID: 30807568OAI: oai:DiVA.org:liu-155578DiVA, id: diva2:1297922
Merknad

Funding Agencies|Swedish Research Council [621-2013-5258]; Knut and Alice Wallenberg Foundation [KAW2011.0165, KAW2012.0101]; Swedish Cancer Foundation [140780, 150663]

Tilgjengelig fra: 2019-03-21 Laget: 2019-03-21 Sist oppdatert: 2020-05-06

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