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Storage-induced change in platelet transfusion response evaluated by serial transfusions from one donor to one patient
Linköping University, Department of Medical and Health Sciences. Linköping University, Faculty of Medicine and Health Sciences. Region Östergötland, Regional Board, Research and Development Unit.
Linköping University, Department of Clinical and Experimental Medicine, Division of Microbiology and Molecular Medicine. Linköping University, Faculty of Medicine and Health Sciences. Region Östergötland, Center for Surgery, Orthopaedics and Cancer Treatment, Department of Haematology.
Linköping University, Department of Clinical and Experimental Medicine. Linköping University, Faculty of Medicine and Health Sciences. Region Östergötland, Center for Diagnostics, Department of Clinical Immunology and Transfusion Medicine.
Linköping University, Department of Clinical and Experimental Medicine. Linköping University, Faculty of Medicine and Health Sciences. Region Östergötland, Center for Surgery, Orthopaedics and Cancer Treatment, Department of Haematology.
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2019 (English)In: Transfusion, ISSN 0041-1132, E-ISSN 1537-2995, Vol. 59, no 2, p. 723-728Article in journal (Refereed) Published
Abstract [en]

BACKGROUND

Storage of platelet concentrates (PCs) results in storage lesions with possible detrimental effects on platelet recovery after transfusion, which might affect their ability to prevent or arrest bleeding. The aim of this study was to compare the quality of PCs stored for 1 to 3 or 5 to 7 days by assessing the corrected count increment (CCI) after transfusion. To isolate the effects of storage time, we studied serial transfusions of PCs obtained from one donor and one donation, and transfused to one single recipient after storage for 1 to 3 days and 5 to 7 days.

STUDY DESIGN AND METHODS

Platelets were obtained from one donor by apheresis, divided into two units (>240 × 109platelets/unit) and stored for 1 to 3 and 5 to 7 days, respectively, before transfusion. The PCs were transfused on normal indications to patients undergoing treatment at the hematology ward. Platelet count was measured before and after transfusion.

RESULTS

Thirty patients concluded the study according to the protocol. The mean storage time was 2.4 ± 0.7 and 5.7 ± 0.8 days for platelets transfused on Days 1 to 3 and 5 to 7, respectively. Storage for 5 to 7 days decreased the 1‐hour transfusion response as compared to platelets stored 1 to 3 days, from a CCI of 17 ± 7 to 13 ± 5. Despite this decrease, 86% of the 5 to 7 days stored PCs resulted in a CCI above the cutoff value for a successful transfusion of 7.5, which was not significantly different to PCs stored for 1 to 3 days.

CONCLUSION

Storage of PCs for 5 to 7 days only slightly altered the transfusion response.

Place, publisher, year, edition, pages
Wiley-Blackwell Publishing Inc., 2019. Vol. 59, no 2, p. 723-728
National Category
Hematology
Identifiers
URN: urn:nbn:se:liu:diva-155595DOI: 10.1111/trf.15079ISI: 000459614500036PubMedID: 30548486Scopus ID: 2-s2.0-85058321870OAI: oai:DiVA.org:liu-155595DiVA, id: diva2:1298667
Note

Funding Agencies|Region Ostergotland

Available from: 2019-03-25 Created: 2019-03-25 Last updated: 2019-07-03Bibliographically approved

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Tynngård, NahreenBoknäs, NiklasTrinks, MarieDreimane, ArtaBerlin, Gösta
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Department of Medical and Health SciencesFaculty of Medicine and Health SciencesResearch and Development UnitDivision of Microbiology and Molecular MedicineDepartment of HaematologyDepartment of Clinical and Experimental MedicineDepartment of Clinical Immunology and Transfusion MedicineDivision of Neuro and Inflammation Science
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