liu.seSearch for publications in DiVA
Change search
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • harvard1
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • oxford
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf
A comparison between single and double cable neuron models applicable to deep brain stimulation
Linköping University, Department of Biomedical Engineering, Division of Biomedical Engineering. Linköping University, Faculty of Science & Engineering. (MINT)
Linköping University, Department of Biomedical Engineering, Division of Biomedical Engineering. Linköping University, Faculty of Science & Engineering. (MINT)ORCID iD: 0000-0002-0012-7867
2019 (English)In: Biomedical Physics & Engineering Express, E-ISSN 2057-1976, Vol. 5, no 2Article in journal (Refereed) Published
Abstract [en]

Computational models for activation assessment in deep brain stimulation (DBS) are commonly based on neuronal cable equations. The aim was to systematically compare the activation distance between a single cable model implemented in MATLAB, and a well-established double cable model implemented in NEURON. Both models have previously been used for DBS studies. The field distributions generated from a point source and a 3389 DBS lead were applied to the neuron models as input stimuli. Simulations (n = 670) were performed with intersecting axon diameters (D) between the models (2.0, 3.0, 5.7, 7.3, 8.7, 10.0 μm), variation in pulse shape and amplitude settings (0 to 5 in increments of 0.5 mA or V) with the single cable model as reference. Both models responded linearly to change of input (point source: 0.93 < R2 < 0.99, DBS source: R2 > 0.98), but with a systematic extended activation distance for the single cable model. The difference for a point source ranged from −0.2 mm (D = 2.0 μm) to −1.1 mm (D = 5.7 μm). For the DBS lead a D = 3.2 μm agreed with the commonly used double cable simulations D =5.7 μm in voltage mode. Possible reasons for the deviation at larger axons are the internodal length, the ion channel selection and physiological data behind the models. The single cable model covers a continuous range of small axon diameters and calculated the internodal length for each iteration, whereas the double cable models uses fixed defined axon diameters and tabulated data for the internodal length. Despite different implementations and model complexities, both models present similar sensitivity to pulse shape, amplitude and axon diameter. With awareness of the strength and weakness both models can be used to extract activation distance used to relate a specific electric field isolevel and thus estimate the volume of tissue activated in DBS simulation studies.

Place, publisher, year, edition, pages
Bibliopolis, Edizioni di Filosofia e Scienze, 2019. Vol. 5, no 2
National Category
Medical Engineering
Identifiers
URN: urn:nbn:se:liu:diva-155800DOI: 10.1088/2057-1976/aafdd9ISI: 000487519600015OAI: oai:DiVA.org:liu-155800DiVA, id: diva2:1299626
Note

Funding agencies: Swedish Foundation [BD15-0032]; Swedish Research CouncilSwedish Research Council [2016-03564]

Available from: 2019-03-28 Created: 2019-03-28 Last updated: 2019-11-04

Open Access in DiVA

fulltext(1849 kB)41 downloads
File information
File name FULLTEXT01.pdfFile size 1849 kBChecksum SHA-512
3cfaeddf5693f750fcf0125e414b99b3b4b8c784d6d7da8286daba2a7051efc1e1ae29f4d578f0dc6d019b9225a67ba1295550b5d85628e3b6f2f52e2c705903
Type fulltextMimetype application/pdf

Other links

Publisher's full text

Authority records BETA

Latorre, MalcolmWårdell, Karin

Search in DiVA

By author/editor
Latorre, MalcolmWårdell, Karin
By organisation
Division of Biomedical EngineeringFaculty of Science & Engineering
Medical Engineering

Search outside of DiVA

GoogleGoogle Scholar
Total: 41 downloads
The number of downloads is the sum of all downloads of full texts. It may include eg previous versions that are now no longer available

doi
urn-nbn

Altmetric score

doi
urn-nbn
Total: 261 hits
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • harvard1
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • oxford
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf