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Myelin Measurement: Comparison Between Simultaneous Tissue Relaxometry, Magnetization Transfer Saturation Index, and T1w/T2w Ratio Methods
Department of Radiology, Juntendo University School of Medicine, Tokyo, Japan. a-hagiwara@juntendo.ac.jp; Department of Radiology, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan.
Department of Radiology, Juntendo University School of Medicine, Tokyo, Japan.
Department of Radiology, Juntendo University School of Medicine, Tokyo, Japan.
Linköping University, Department of Medical and Health Sciences, Division of Cardiovascular Medicine. Linköping University, Faculty of Medicine and Health Sciences. Linköping University, Center for Medical Image Science and Visualization (CMIV). Region Östergötland, Heart and Medicine Center, Department of Clinical Physiology in Linköping. SyntheticMR AB, Linköping, Sweden.
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2018 (English)In: Scientific Reports, ISSN 2045-2322, E-ISSN 2045-2322, Vol. 8, no 1, article id 10554Article in journal (Refereed) Published
Abstract [en]

Magnetization transfer (MT) imaging has been widely used for estimating myelin content in the brain. Recently, two other approaches, namely simultaneous tissue relaxometry of R1 and R2 relaxation rates and proton density (SyMRI) and the ratio of T1-weighted to T2-weighted images (T1w/T2w ratio), were also proposed as methods for measuring myelin. SyMRI and MT imaging have been reported to correlate well with actual myelin by histology. However, for T1w/T2w ratio, such evidence is limited. In 20 healthy adults, we examined the correlation between these three methods, using MT saturation index (MTsat) for MT imaging. After calibration, white matter (WM) to gray matter (GM) contrast was the highest for SyMRI among these three metrics. Even though SyMRI and MTsat showed strong correlation in the WM (r?=?0.72), only weak correlation was found between T1w/T2w and SyMRI (r?=?0.45) or MTsat (r?=?0.38) (correlation coefficients significantly different from each other, with p values?amp;lt;?0.001). In subcortical and cortical GM, these measurements showed moderate to strong correlations to each other (r?=?0.54 to 0.78). In conclusion, the high correlation between SyMRI and MTsat indicates that both methods are similarly suited to measure myelin in the WM, whereas T1w/T2w ratio may be less optimal.

Place, publisher, year, edition, pages
Nature Publishing Group, 2018. Vol. 8, no 1, article id 10554
National Category
Radiology, Nuclear Medicine and Medical Imaging
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URN: urn:nbn:se:liu:diva-155995DOI: 10.1038/s41598-018-28852-6ISI: 000438343600064PubMedID: 30002497Scopus ID: 2-s2.0-85049902091OAI: oai:DiVA.org:liu-155995DiVA, id: diva2:1301099
Available from: 2019-04-01 Created: 2019-04-01 Last updated: 2019-10-09Bibliographically approved

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Warntjes, Marcel

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Division of Cardiovascular MedicineFaculty of Medicine and Health SciencesCenter for Medical Image Science and Visualization (CMIV)Department of Clinical Physiology in Linköping
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