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Adrenaline enhances in vitro platelet activation and aggregation in blood samples from ticagrelor-treated patients
Department of Molecular and Clinical Medicine Institute of Medicine Sahlgrenska Academy University of Gothenburg Gothenburg Sweden.
Department of Molecular and Clinical Medicine Institute of Medicine Sahlgrenska Academy University of Gothenburg Gothenburg, Sweden.
Linköping University, Department of Clinical and Experimental Medicine, Division of Microbiology and Molecular Medicine. Linköping University, Faculty of Medicine and Health Sciences. Region Östergötland, Center for Diagnostics, Department of Clinical Chemistry. School of Medical Sciences Örebro University Örebro,Sweden.ORCID iD: 0000-0002-1920-3962
Department of Clinical Chemistry and Transfusion Medicine Institute of Biomedicine Sahlgrenska Academy University of Gothenburg Gothenburg Sweden; Regional Blood Bank Sahlgrenska University Hospital Gothenburg, Sweden.
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2018 (English)In: Research and practice in thrombosis and haemostasis, ISSN 2475-0379, Vol. 2, no 4, p. 718-725Article in journal (Refereed) Published
Abstract [en]

Temporarily improved platelet reactivity may reduce the bleeding in patients on antiplatelet therapy who have ongoing bleeding or who are in need of acute surgery. Adrenaline can bind to adrenergic a2A-receptors on platelets and potentially enhance platelet reactivity.

Place, publisher, year, edition, pages
John Wiley & Sons, 2018. Vol. 2, no 4, p. 718-725
Keywords [en]
adrenaline; flow cytometry; platelet aggregation; platelet aggregation inhibitors; platelet function tests
National Category
Hematology
Identifiers
URN: urn:nbn:se:liu:diva-156017DOI: 10.1002/rth2.12149PubMedID: 30349891OAI: oai:DiVA.org:liu-156017DiVA, id: diva2:1301581
Available from: 2019-04-02 Created: 2019-04-02 Last updated: 2019-04-02

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Ramström, Sofia

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Division of Microbiology and Molecular MedicineFaculty of Medicine and Health SciencesDepartment of Clinical Chemistry
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