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Recovery of layered tissue optical properties from spatial frequency-domain spectroscopy and a deterministic radiative transport solver
University of California, Department of Mathematics, Irvine, California, United States; University of California, Beckman Laser Institute, Laser Microbeam and Medical Program, Irvine, Cali, United States.
University of California, Beckman Laser Institute, Laser Microbeam and Medical Program, Irvine, Cali, United States; University of California, Department of Chemical Engineering and Materials Science, Irvine, Californ, United States.
Linköping University, Department of Biomedical Engineering, Division of Biomedical Engineering. Linköping University, Faculty of Science & Engineering. University of California, Beckman Laser Institute, Laser Microbeam and Medical Program, Irvine, Cali, United States.
University of California, Beckman Laser Institute, Laser Microbeam and Medical Program, Irvine, Cali, United States; University of California, Department of Biomedical Engineering, Irvine, California, United States.
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2018 (English)In: Journal of Biomedical Optics, ISSN 1083-3668, E-ISSN 1560-2281, Vol. 24, no 7, article id 071607Article in journal (Refereed) Published
Abstract [en]

We present a method to recover absorption and reduced scattering spectra for each layer of a two-layer turbid media from spatial frequency-domain spectroscopy data. We focus on systems in which the thickness of the top layer is less than the transport mean free path   (  0.1  −  0.8<i>l</i><sup>  *  </sup>  )  . We utilize an analytic forward solver, based upon the <i>N</i>’th-order spherical harmonic expansion with Fourier decomposition   (  SHEF<sub>N</sub>  )   method in conjunction with a multistage inverse solver. We test our method with data obtained using spatial frequency-domain spectroscopy with 32 evenly spaced wavelengths within λ  =  450 to 1000 nm on six-layered tissue phantoms with distinct optical properties. We demonstrate that this approach can recover absorption and reduced scattering coefficient spectra for both layers with accuracy comparable with current Monte Carlo methods but with lower computational cost and potential flexibility to easily handle variations in parameters such as the scattering phase function or material refractive index. To our knowledge, this approach utilizes the most accurate deterministic forward solver used in such problems and can successfully recover properties from a two-layer media with superficial layer thicknesses.

Place, publisher, year, edition, pages
SPIE - International Society for Optical Engineering, 2018. Vol. 24, no 7, article id 071607
Keywords [en]
analytic solver; inverse problem; spatial frequency domain; staged inversion
National Category
Atom and Molecular Physics and Optics
Identifiers
URN: urn:nbn:se:liu:diva-156065DOI: 10.1117/1.JBO.24.7.071607PubMedID: 30456934OAI: oai:DiVA.org:liu-156065DiVA, id: diva2:1301750
Available from: 2019-04-02 Created: 2019-04-02 Last updated: 2019-04-02

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