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Reduced workforce participation 5 years prior to first Parkinsons disease sick-leave
Department of Clinical Sciences Lund, Neurology, Lund University, Lund, Sweden; 2Department of Neurology, Skåne University Hospital, Lund, Sweden.
Linköping University, Department of Behavioural Sciences and Learning, Psychology. Linköping University, Faculty of Arts and Sciences. (Athletics Research Center)
Linköping University, Department of Medical and Health Sciences, Division of Community Medicine. Linköping University, Faculty of Medicine and Health Sciences. Region Östergötland, Center for Business support and Development, Department of Health and Care Development.
Department of Health Sciences, Lund University, Lund, Sweden; 8Memory Clinic, Skåne University Hospital, Malmö, Sweden.
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2018 (English)In: NPJ Parkinsons disease, ISSN 2373-8057, Vol. 4, article id 36Article in journal (Refereed) Published
Abstract [en]

The importance of understanding the prodromal phase of Parkinsons disease (PD) by systematic recording of prediagnostic symptoms and reductions in body functions has been highlighted. The aim of this study was to investigate whether persons later diagnosed with PD exhibit increased physician-certified sickness absence 1, 2, and 5 years prior to a first sick-leave episode attributed to PD. A case-control study was performed to analyze data from all nontrivial (exceeding 14 days) sick-leave episodes in Sweden between 2008 and 2014. The 537 incident PD sick-leave episodes were identified as PD sick-leave cases and compared to 537 sick-leave controls identified by matching age, sex, and date of the first day of the sick-leave episode. The total sickness absence and sickness absence due to musculoskeletal diagnoses were found to be increased among the PD sick-leave cases from 5 years prior to the first sick-leave episode ascribed to PD when compared to the controls. No differences between PD sick-leave cases and sick-leave controls were found with regard to mental and behavioral diagnoses. We conclude that the capacity to participate in working life is reduced already at the early prediagnostic stages of PD. This finding can be used as a basis for further research into the process of identifying individuals at risk for developing PD, particularly in combination with further investigation into biochemical, genetic, and imaging biomarkers.

Place, publisher, year, edition, pages
Nature Publishing Group, 2018. Vol. 4, article id 36
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General Practice
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URN: urn:nbn:se:liu:diva-156078DOI: 10.1038/s41531-018-0072-2ISI: 000454257200001PubMedID: 30564630OAI: oai:DiVA.org:liu-156078DiVA, id: diva2:1301766
Available from: 2019-04-02 Created: 2019-04-02 Last updated: 2019-06-28Bibliographically approved

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Spreco, ArminTimpka, Toomas

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Dahlström, ÖrjanSpreco, ArminTimpka, Toomas
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PsychologyFaculty of Arts and SciencesDivision of Community MedicineFaculty of Medicine and Health SciencesDepartment of Health and Care Development
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