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Expression of Immune Regulatory Genes in the Porcine Internal Genital Tract Is Differentially Triggered by Spermatozoa and Seminal Plasma
Linköpings universitet, Institutionen för klinisk och experimentell medicin, Avdelningen för barns och kvinnors hälsa. Linköpings universitet, Medicinska fakulteten.ORCID-id: 0000-0003-0120-354X
Linköpings universitet, Institutionen för klinisk och experimentell medicin. Linköpings universitet, Medicinska fakulteten. Department of Surgery and Theriogenology, Faculty of Veterinary Animal and Biomedical Sciences, Sylhet Agricultural University, Sylhet, Bangladesh.ORCID-id: 0000-0001-8425-7505
Linköpings universitet, Institutionen för klinisk och experimentell medicin. Linköpings universitet, Medicinska fakulteten. University of Helsinki, Department of Production Animal Medicine, Faculty of Veterinary Medicine, Saari, Finland.
Linköpings universitet, Institutionen för fysik, kemi och biologi, Biologi. Linköpings universitet, Tekniska fakulteten.ORCID-id: 0000-0003-2329-2635
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2019 (engelsk)Inngår i: International Journal of Molecular Sciences, ISSN 1422-0067, E-ISSN 1422-0067, Vol. 20, nr 3, artikkel-id 513Artikkel i tidsskrift (Fagfellevurdert) Published
Abstract [en]

Mating or cervical deposition of spermatozoa or seminal plasma (SP) modifies the expression of genes affecting local immune defense processes at the oviductal sperm reservoir in animals with internal fertilization, frequently by down-regulation. Such responses may occur alongside sperm transport to or even beyond the reservoir. Here, immune-related gene expression was explored with cDNA microarrays on porcine cervix-to-infundibulum tissues, pre-/peri-ovulation. Samples were collected 24 h post-mating or cervical deposition of sperm-peak spermatozoa or SP (from the sperm-peak fraction or the whole ejaculate). All treatments of this interventional study affected gene expression. The concerted action of spermatozoa and SP down-regulated chemokine and cytokine (P00031), interferon-gamma signaling (P00035), and JAK/STAT (P00038) pathways in segments up to the sperm reservoir (utero-tubal junction (UTJ)/isthmus). Spermatozoa in the vanguard sperm-peak fraction (P1-AI), uniquely displayed an up-regulatory effect on these pathways in the ampulla and infundibulum. Sperm-free SP, on the other hand, did not lead to major effects on gene expression, despite the clinical notion that SP mitigates reactivity by the female immune system after mating or artificial insemination.

sted, utgiver, år, opplag, sider
MDPI, 2019. Vol. 20, nr 3, artikkel-id 513
Emneord [en]
transcriptomics; microarray; bioinformatics; spermatozoa; seminal plasma; immune-regulation; female internal genitalia; pig
HSV kategori
Identifikatorer
URN: urn:nbn:se:liu:diva-156214DOI: 10.3390/ijms20030513ISI: 000462412500057PubMedID: 30691059Scopus ID: 2-s2.0-85060587196OAI: oai:DiVA.org:liu-156214DiVA, id: diva2:1303217
Merknad

Funding Agencies|Research Council FORMAS, Stockholm [2017-00946]; Swedish Research Council (Vetenskapsradet, VR) [2015-05919]

Tilgjengelig fra: 2019-04-09 Laget: 2019-04-09 Sist oppdatert: 2019-10-18bibliografisk kontrollert

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Alvarez-Rodriguez, ManuelAtikuzzaman, MohammadVenhoranta, HeliWright, DominicRodriguez-Martinez, Heriberto

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