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Expression of Immune Regulatory Genes in the Porcine Internal Genital Tract Is Differentially Triggered by Spermatozoa and Seminal Plasma
Linköping University, Department of Clinical and Experimental Medicine, Division of Children's and Women's health. Linköping University, Faculty of Medicine and Health Sciences.ORCID iD: 0000-0003-0120-354X
Linköping University, Department of Clinical and Experimental Medicine. Linköping University, Faculty of Medicine and Health Sciences. Department of Surgery and Theriogenology, Faculty of Veterinary Animal and Biomedical Sciences, Sylhet Agricultural University, Sylhet, Bangladesh.ORCID iD: 0000-0001-8425-7505
Linköping University, Department of Clinical and Experimental Medicine. Linköping University, Faculty of Medicine and Health Sciences. University of Helsinki, Department of Production Animal Medicine, Faculty of Veterinary Medicine, Saari, Finland.
Linköping University, Department of Physics, Chemistry and Biology, Biology. Linköping University, Faculty of Science & Engineering.ORCID iD: 0000-0003-2329-2635
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2019 (English)In: International Journal of Molecular Sciences, ISSN 1422-0067, E-ISSN 1422-0067, Vol. 20, no 3, article id 513Article in journal (Refereed) Published
Abstract [en]

Mating or cervical deposition of spermatozoa or seminal plasma (SP) modifies the expression of genes affecting local immune defense processes at the oviductal sperm reservoir in animals with internal fertilization, frequently by down-regulation. Such responses may occur alongside sperm transport to or even beyond the reservoir. Here, immune-related gene expression was explored with cDNA microarrays on porcine cervix-to-infundibulum tissues, pre-/peri-ovulation. Samples were collected 24 h post-mating or cervical deposition of sperm-peak spermatozoa or SP (from the sperm-peak fraction or the whole ejaculate). All treatments of this interventional study affected gene expression. The concerted action of spermatozoa and SP down-regulated chemokine and cytokine (P00031), interferon-gamma signaling (P00035), and JAK/STAT (P00038) pathways in segments up to the sperm reservoir (utero-tubal junction (UTJ)/isthmus). Spermatozoa in the vanguard sperm-peak fraction (P1-AI), uniquely displayed an up-regulatory effect on these pathways in the ampulla and infundibulum. Sperm-free SP, on the other hand, did not lead to major effects on gene expression, despite the clinical notion that SP mitigates reactivity by the female immune system after mating or artificial insemination.

Place, publisher, year, edition, pages
MDPI, 2019. Vol. 20, no 3, article id 513
Keywords [en]
transcriptomics; microarray; bioinformatics; spermatozoa; seminal plasma; immune-regulation; female internal genitalia; pig
National Category
Medical Genetics
Identifiers
URN: urn:nbn:se:liu:diva-156214DOI: 10.3390/ijms20030513ISI: 000462412500057PubMedID: 30691059Scopus ID: 2-s2.0-85060587196OAI: oai:DiVA.org:liu-156214DiVA, id: diva2:1303217
Note

Funding Agencies|Research Council FORMAS, Stockholm [2017-00946]; Swedish Research Council (Vetenskapsradet, VR) [2015-05919]

Available from: 2019-04-09 Created: 2019-04-09 Last updated: 2019-10-18Bibliographically approved

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Alvarez-Rodriguez, ManuelAtikuzzaman, MohammadVenhoranta, HeliWright, DominicRodriguez-Martinez, Heriberto

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Alvarez-Rodriguez, ManuelAtikuzzaman, MohammadVenhoranta, HeliWright, DominicRodriguez-Martinez, Heriberto
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