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Possible Role and Therapeutic Target of PDGF-D Signalling in Colorectal Cancer
Linköpings universitet, Institutionen för medicin och hälsa, Avdelningen för läkemedelsforskning. Linköpings universitet, Medicinska fakulteten. Dept Lab Med, Sweden.
Jonkoping Univ, Sweden.
Helmholtz Ctr Infect Res, Germany.
Linköpings universitet, Institutionen för medicin och hälsa, Avdelningen för läkemedelsforskning. Linköpings universitet, Medicinska fakulteten.
2019 (engelsk)Inngår i: Cancer Investigation, ISSN 0735-7907, E-ISSN 1532-4192, Vol. 37, nr 2, s. 99-112Artikkel i tidsskrift (Fagfellevurdert) Published
Abstract [en]

Platelet-derived growth factor D (PDGF-D) has been shown to mediate cellular processes of importance in cancer progression. This study aimed to investigate the expression and putative involvement of PDGF-D signaling in colorectal carcinogenesis. PDGF-D was expressed in vascular endothelial cells in tumor and normal tissues. PDGF-D stimulation of cells altered genes of importance in carcinogenic processes. In addition, PDGF-D increased the proliferation rate while imatinib inhibited these effects. PDGF-D and its PDGF receptor beta (PDGFR-beta) are expressed in colorectal cancer and blockage of PDGF-D/PDGFR-beta signaling using tyrosine kinase inhibitors, such as imatinib, might be important in inhibiting tumor-promoting actions.

sted, utgiver, år, opplag, sider
TAYLOR & FRANCIS INC , 2019. Vol. 37, nr 2, s. 99-112
Emneord [en]
Angiogenesis; Colorectal cancer; Imatinib; PDGF-D; Proliferation
HSV kategori
Identifikatorer
URN: urn:nbn:se:liu:diva-156212DOI: 10.1080/07357907.2019.1576191ISI: 000462343500005PubMedID: 30836770OAI: oai:DiVA.org:liu-156212DiVA, id: diva2:1303218
Merknad

Funding Agencies|Foundation of Clinical Cancer Research, Jonkoping, Sweden [110426-1]; Futurum - the Academy for Health and Care, County Council of Jonkoping, Sweden [FUTURUM-105891]; FORSS, the Research Council of South-Eastern Sweden, Sweden [FORSS-373251]

Tilgjengelig fra: 2019-04-09 Laget: 2019-04-09 Sist oppdatert: 2019-04-09

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