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Detection of ureaplasmas and bacterial vaginosis associated bacteria and their association with non-gonococcal urethritis in men
Research Unit for Reproductive Microbiology, Statens Serum Institut, Copenhagen S, Denmark.
Linköping University, Department of Clinical and Experimental Medicine, Division of Microbiology, Infection and Inflammation. Linköping University, Faculty of Medicine and Health Sciences. Region Östergötland, Heart and Medicine Center, Department of Dermatology and Venerology.ORCID iD: 0000-0001-8336-9767
Research Unit for Reproductive Microbiology, Statens Serum Institut, Copenhagen S, Denmark.
Research Unit for Reproductive Microbiology, Statens Serum Institut, Copenhagen S, Denmark.
2019 (English)In: PLoS ONE, ISSN 1932-6203, E-ISSN 1932-6203Article in journal (Refereed) Published
Abstract [en]

No aetiology is found in up to 40% of men with symptomatic urethritis. Male partners of women with bacterial vaginosis (BV) may be at higher risk of non-gonococcal urethritis (NGU). The aim of this study was to examine the role of BV associated bacteria in first-void urine (FVU) in 97 asymptomatic men without urethritis (controls) and 44 men (cases) with NGU including 20 men with idiopathic urethritis (IU) attending a Swedish STD-clinic between January and October 2010. BV-associated bacteria and ureaplasmas were detected by quantitative PCR assays. All BV associated bacteria, except Megasphaera-like type 1, were strongly positively correlated with Uurealyticum p<0.005 and even stronger with the combined Uurealyticum and Uparvum load (p<0.0005) suggesting that ureaplasma induced elevated pH may stimulate the growth of BV associated bacteria. No statistically significant differences were found between IU cases and controls in the prevalence or load of BV associated bacteria or ureaplasmas. In multiple logistic regression, Megasphaera-like type 1 was associated with IU (p = 0.03), but most positive FVU samples contained very few bacteria and the finding may not be clinically relevant.

Place, publisher, year, edition, pages
San Francisco, CA, United States: Public Library of Science , 2019.
National Category
Dermatology and Venereal Diseases
Identifiers
URN: urn:nbn:se:liu:diva-156363DOI: 10.1371/journal.pone.0214425ISI: 000463314500031PubMedID: 30946763Scopus ID: 2-s2.0-85063929258OAI: oai:DiVA.org:liu-156363DiVA, id: diva2:1305560
Note

Funding agencies:  ALF-Grant [LIO-205751]; County Council of Ostergotland, Sweden; ALF-Grant from County Council of Ostergotland, Sweden [LIO-205751, LIO-60221, LIO-60311]

Available from: 2019-04-17 Created: 2019-04-17 Last updated: 2019-06-12Bibliographically approved

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Division of Microbiology, Infection and InflammationFaculty of Medicine and Health SciencesDepartment of Dermatology and Venerology
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