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Modified lipoproteins in periodontitis: a link to cardiovascular disease?
Linköping University, Department of Clinical and Experimental Medicine, Division of Neuro and Inflammation Science. Linköping University, Faculty of Medicine and Health Sciences.
Orebro Univ, Sweden.
Linköping University, Department of Clinical and Experimental Medicine, Division of Neuro and Inflammation Science. Region Östergötland, Heart and Medicine Center, Occupational and Environmental Medicine Center. Linköping University, Faculty of Medicine and Health Sciences.
Linköping University, Department of Medical and Health Sciences, Division of Cardiovascular Medicine. Linköping University, Faculty of Medicine and Health Sciences. Region Östergötland, Public Dental Health Care.
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2019 (English)In: Bioscience Reports, ISSN 0144-8463, E-ISSN 1573-4935, Vol. 39, no 3, article id BSR20181665Article in journal (Refereed) Published
Abstract [en]

There is a strong association between periodontal disease and atherosclerotic cardiovascular disorders. A key event in the development of atherosclerosis is accumulation of modified lipoproteins within the arterial wall. We hypothesise that patients with periodontitis have an altered lipoprotein profile towards an atherogenic form. Therefore, the present study aims at identifying modifications of plasma lipoproteins in periodontitis. Lipoproteins from ten female patients with periodontitis and gender- and age-matched healthy controls were isolated by density-gradient ultracentrifugation. Proteins were separated by 2D gel-electrophoresis and identified by map-matching or by nano-LC followed by MS. Apolipoprotein (Apo) A-I (ApoA-I) methionine oxidation, Oxyblot, total antioxidant capacity and a multiplex of 71 inflammation-related plasma proteins were assessed. Reduced levels of apoJ, phospholipid transfer protein, apoF, complement C3, paraoxonase 3 and increased levels of alpha-1-antichymotrypsin, apoA-II, apoC-III were found in high-density lipoprotein (HDL) from the patients. In low-density lipoprotein (LDL)/very LDL (VLDL), the levels of apoL-1 and platelet-activating factor acetylhydrolase (PAF-AH) as well as apo-B fragments were increased. Methionine oxidation of apoA-I was increased in HDL and showed a relationship with periodontal parameters. alpha-1 antitrypsin and alpha-2-HS glycoprotein were oxidised in LDL/VLDL and antioxidant capacity was increased in the patient group. A total of 17 inflammation-related proteins were important for group separation with the highest discriminating proteins identified as IL-21, Fractalkine, IL-17F, IL-7, IL-1RA and IL-2. Patients with periodontitis have an altered plasma lipoprotein profile, defined by altered protein levels as well as post-translational and other structural modifications towards an atherogenic form, which supports a role of modified plasma lipoproteins as central in the link between periodontal and cardiovascular disease (CVD).

Place, publisher, year, edition, pages
Portland Press, 2019. Vol. 39, no 3, article id BSR20181665
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Cardiac and Cardiovascular Systems
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URN: urn:nbn:se:liu:diva-157252DOI: 10.1042/BSR20181665ISI: 000465453700016PubMedID: 30842338Scopus ID: 2-s2.0-85063936955OAI: oai:DiVA.org:liu-157252DiVA, id: diva2:1320229
Note

Funding Agencies|Swedish Knowledge Foundation [Dnr20150037]; Foundation Langmanska Kulturfonden; Magnus Bergwalls Foundation

Available from: 2019-06-04 Created: 2019-06-04 Last updated: 2019-06-10Bibliographically approved

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Ljunggren, StefanKarlsson, HelenStarkhammar Johansson, CarinNayeri, FaribaGhafouri, BijarLönn, Johanna

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Ljunggren, StefanKarlsson, HelenStarkhammar Johansson, CarinNayeri, FaribaGhafouri, BijarLönn, Johanna
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Division of Neuro and Inflammation ScienceFaculty of Medicine and Health SciencesOccupational and Environmental Medicine CenterDivision of Cardiovascular MedicinePublic Dental Health CareDivision of Microbiology, Infection and InflammationDepartment of Infectious DiseasesDivision of Community MedicinePain and Rehabilitation CenterPharmacologyFaculty of Health Sciences
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