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Cigarette smoking affects microRNAs and inflammatory biomarkers in healthy individuals and an association to single nucleotide polymorphisms is indicated
Linköping University, Department of Clinical and Experimental Medicine, Division of Surgery, Orthopedics and Oncology. Linköping University, Faculty of Medicine and Health Sciences. Ryhov Cty Hosp, Sweden.
Inst Postgrad Dent Educ, Sweden.
Ryhov Cty Hosp, Sweden.
Swedish Match AB, Sweden.
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2019 (English)In: Biomarkers, ISSN 1354-750X, E-ISSN 1366-5804, Vol. 24, no 2, p. 180-185Article in journal (Refereed) Published
Abstract [en]

Background: Cigarette smoke induces inflammation and remodels immune response. Genetic and epigenetic alterations might be involved in the pathogenesis of smoking related diseases. In this study, we investigated the effect of smoking on systemic inflammation biomarkers and epigenetic changes at microRNA (miRNA) expression level. We also examined if the levels of inflammatory biomarkers were associated with selected single nucleotide polymorphisms (SNPs). Method: From 39 smokers and 101 non-smokers, levels of total white blood cells (WBCs) and its subpopulations, plasma cytokines/chemokines/proteins and miRNAs were analysed. For three biomarkers, C-reactive protein (CRP), MCP-1 and IFN-gamma that were affected by smoking, the influence of SNPs was analyzed. Result: Elevated levels of total WBCs, neutrophils, monocytes, lymphocytes, CRP, MCP-1, IFN-gamma and lower levels of miR-21 were detected in smokers. The elevated levels of IFN-gamma in smokers was only statistically significantly associated with rs2069705 AG/GG SNP-genotype. Conclusions: A lower level of oncomir miRNA-21 and a higher level of immune modelling cytokine IFN-gamma detected in smokers could be a protective immune response to cigarette smoke. The higher level of IFN-gamma in smokers with a specific SNP genotype also suggests that a genetic interaction with smoking might predict the pathobiology of smoking related disease.

Place, publisher, year, edition, pages
TAYLOR & FRANCIS LTD , 2019. Vol. 24, no 2, p. 180-185
Keywords [en]
Immune respons; single nucleotide polymorphism; microRNA; smoking related diseases; cigarette smoking
National Category
Rheumatology and Autoimmunity
Identifiers
URN: urn:nbn:se:liu:diva-157272DOI: 10.1080/1354750X.2018.1539764ISI: 000465158700011PubMedID: 30375257OAI: oai:DiVA.org:liu-157272DiVA, id: diva2:1323809
Note

Funding Agencies|Forskningsradet i Sydostra Sverige; Futurum-Academy of HealthCare at Jonkoping County Council [477461, 490031, 669631]; Foundation of Clinical Cancer Research in Jo nkoping [110426-1]; Medical Research Council of Southeast Sweden (FORSS) [567001]

Available from: 2019-06-12 Created: 2019-06-12 Last updated: 2019-06-12

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Andersson, Bengt-ÅkeLewin, Nongnit
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Division of Surgery, Orthopedics and OncologyFaculty of Medicine and Health Sciences
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