liu.seSearch for publications in DiVA
Change search
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • oxford
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf
Capillary-Fiber Based Electrophoretic Delivery Device
Linköping University, Department of Science and Technology, Laboratory of Organic Electronics. Linköping University, Faculty of Science & Engineering.ORCID iD: 0000-0002-4246-8723
Linköping University, Department of Science and Technology, Laboratory of Organic Electronics. Linköping University, Faculty of Science & Engineering.ORCID iD: 0000-0002-0302-226X
Linköping University, Department of Science and Technology, Physics and Electronics. Linköping University, Faculty of Science & Engineering. Ist Italiano Tecnol, Italy; St Anna Sch Adv Studies, Italy.
Linköping University, Department of Science and Technology, Laboratory of Organic Electronics. Linköping University, Faculty of Science & Engineering. Res Inst Sweden, Sweden.
Show others and affiliations
2019 (English)In: ACS Applied Materials and Interfaces, ISSN 1944-8244, E-ISSN 1944-8252, Vol. 11, no 15, p. 14200-14207Article in journal (Refereed) Published
Abstract [en]

Organic electronic ion pumps (OEIPs) are versatile tools for electrophoretic delivery of substances with high spatiotemporal resolution. To date, OEIPs and similar iontronic components have been fabricated using thin-film techniques and often rely on laborious, multistep photolithographic processes. OEIPs have been demonstrated in a variety of in vitro and in vivo settings for controlling biological systems, but the thin-film form factor and limited repertoire of polyelectrolyte materials and device fabrication techniques unnecessarily constrain the possibilities for miniaturization and extremely localized substance delivery, e.g., the greater range of pharmaceutical compounds, on the scale of a single cell. Here, we demonstrate an entirely new OEIP form factor based on capillary fibers that include hyperbranched polyglycerols (dPGs) as the selective electrophoretic membrane. The dPGs enable electrophoretic channels with a high concentration of fixed charges and well-controlled cross-linking and can be realized using a simple one-pot fluidic manufacturing protocol. Selective electrophoretic transport of cations and anions of various sizes is demonstrated, including large substances that are difficult to transport with other OEIP technologies. We present a method for tailoring and characterizing the electrophoretic channels fixed charge concentration in the operational state. Subsequently, we compare the experimental performance of these capillary OEIPs to a computational model and explain unexpected features in the ionic current for the transport and delivery of larger, lower-mobility ionic compounds. From this model, we are able to elucidate several operational and design principles relevant to miniaturized electrophoretic drug delivery technologies in general. Overall, the compactness of the capillary OEIP enables electrophoretic delivery devices with probelike geometries, suitable for a variety of ionic compounds, paving the way for less-invasive implantation into biological systems and for healthcare applications.

Place, publisher, year, edition, pages
AMER CHEMICAL SOC , 2019. Vol. 11, no 15, p. 14200-14207
Keywords [en]
electrophoresis; polyelectrolyte; iontronics; hyperbranched polymer; bioelectronics; substance delivery
National Category
Other Physics Topics
Identifiers
URN: urn:nbn:se:liu:diva-157207DOI: 10.1021/acsami.8b022680ISI: 000465189000042OAI: oai:DiVA.org:liu-157207DiVA, id: diva2:1324726
Note

Funding Agencies|Swedish Foundation for Strategic Research; Swedish Government Strategic Research Area in Materials Science on Advanced Functional Materials at Linkoping University (Faculty Grant SFO-Mat-LiU) [2009-00971]; Onnesjo Foundation; Knut and Alice Wallenberg Foundation

Available from: 2019-06-14 Created: 2019-06-14 Last updated: 2024-01-10
In thesis
1. Synthetic Functionalities for Ion and Electron Conductive Polymers: Applications in Organic Electronics and Biological Interfaces
Open this publication in new window or tab >>Synthetic Functionalities for Ion and Electron Conductive Polymers: Applications in Organic Electronics and Biological Interfaces
2021 (English)Doctoral thesis, comprehensive summary (Other academic)
Abstract [en]

In the search for understanding and communicating with all biological systems, in humans, animals, plants, and even microorganisms, we find a common language of all communicating via electrons, ions and molecules. Since the discovery of organic electronics, the ability to bridge the gap and communicate be-tween modern technology and biology has emerged. Organic chemistry pro-vides us with tools for understanding and a material platform of polymer electronics for communication. Such insights give us not only the ability to observe fundamental phenomenon but to actively design and construct materials with chemical functionalities towards better interfaces and applications. Organic electronic materials and devices have found their way to be implemented in the field of medicine for diagnostic and therapeutic purposes, but also in water purification and to help tackle the monumental task in creating the next generation of sustainable energy production and storage. Ultimately it’s safe to say that organic electronics are not going to replace our traditional technology based on inorganic materials but rather the two fields can find a way to complement each other for various purposes and applications. Compared to conventional silicon based technology, production of carbon-based organic electronic polymer materials are extremely cheap and devices can even be made flexible and soft with great compatibility towards biology.  

The main focus of this thesis has been developing and synthesizing new types of organic electronic and ionic conductive polymeric materials. Rational chemical design and modifications of the materials have been utilized to introduce specific functionalities to the materials. The functionalities serving the purpose to facilitate ion and electron conductive charge transport for organic electronics and with biological interface implementation of the polymer materials. 

Multi-functional ionic conductive hyperbranched polyglycerol polyelectrolytes (dendrolytes) were developed comprising both ionically charged groups and cross-linkable groups. The hyperbranched polyglycerol core structure of the material possesses a hydrophilic solvating platform for both ions and maintenance of solvent molecules, while being a biocompatible structure. Coupled with the peripheral charged ionic functionalities of the polymer, the dendrolyte materials are highly ionic conductive and selective towards cationic and anionic charged atoms and large molecules when implemented as ion-exchange membranes. Homogenous ion-exchange membrane casting has been achieved by the implementation of cross-linkable functionalities in the dendrolytes, utilizing robust click-chemistry for efficient micro and macro fabrication processing of the ion-ex-change membranes for organic electronic devices. The ion-exchange membrane material was implemented in electrophoretic drug delivery devices (organic electronic ion pumps), which are used for delivery of ions and neurotransmitters with spatiotemporal resolution and are able to communicate and be used for therapeutic drug delivery purposes in biological interfaces. The dendrolyte materials were also able to form free-standing membranes, making it possible for implementation in fuel cell and desalination purposes. 

Trimeric conjugated thiophene pre-polymer structures were also developed in the thesis and synthesized for the purpose of implementation of the material in vivo to form electrically conductive polymer structures, and in such manner to be able to create electrodes and ultimately to connect with the central nervous system. The conjugated pre-polymers being both water soluble and enzymatically polymerizable serve as a platform to realize such a concept. Also, modifying the trimeric structure with cross-linkable functionality created the capability to form better interfaces and stability towards biological environments.   

Place, publisher, year, edition, pages
Linköping: Linköping University Electronic Press, 2021. p. 97
Series
Linköping Studies in Science and Technology. Dissertations, ISSN 0345-7524 ; 2193
National Category
Polymer Chemistry
Identifiers
urn:nbn:se:liu:diva-181717 (URN)10.3384/9789179291341 (DOI)9789179291334 (ISBN)9789179291341 (ISBN)
Public defence
2022-01-14, K1, Kåkenhus, Campus Norrköping, Norrköping, 10:15 (English)
Opponent
Supervisors
Available from: 2021-12-07 Created: 2021-12-07 Last updated: 2021-12-07Bibliographically approved

Open Access in DiVA

fulltext(2047 kB)338 downloads
File information
File name FULLTEXT01.pdfFile size 2047 kBChecksum SHA-512
3b91aa9b6d8d6b74d7ce1ab43fdeea4eccce756945b843e1837496314113125ac8cb3d203cb3d9aa4f0b1e40503f165c297ce5f4a55d6fa6b4260e8ff782467d
Type fulltextMimetype application/pdf

Other links

Publisher's full text

Search in DiVA

By author/editor
Poxson, DavidGabrielsson, ErikBonisoli, AlbertoLinderhed, UlrikaAbrahamsson, TobiasMatthiesen, IsabelleTybrandt, KlasBerggren, MagnusSimon, Daniel
By organisation
Laboratory of Organic ElectronicsFaculty of Science & EngineeringPhysics and Electronics
In the same journal
ACS Applied Materials and Interfaces
Other Physics Topics

Search outside of DiVA

GoogleGoogle Scholar
Total: 338 downloads
The number of downloads is the sum of all downloads of full texts. It may include eg previous versions that are now no longer available

doi
urn-nbn

Altmetric score

doi
urn-nbn
Total: 1109 hits
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • oxford
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf