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Minimally Invasive versus Open Distal Pancreatectomy for Ductal Adenocarcinoma (DIPLOMA)
Acad Med Ctr, Netherlands.
Acad Med Ctr, Netherlands.
Acad Med Ctr, Netherlands.
Southampton Univ Hosp NHS Fdn Trust, England.
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2019 (Engelska)Ingår i: Annals of Surgery, ISSN 0003-4932, E-ISSN 1528-1140, Vol. 269, nr 1, s. 10-17Artikel i tidskrift (Refereegranskat) Published
Abstract [en]

Objective: The aim of this study was to compare oncological outcomes after minimally invasive distal pancreatectomy (MIDP) with open distal pancreatectomy (ODP) in patients with pancreatic ductal adenocarcinoma (PDAC).

Background: Cohort studies have suggested superior short-term outcomes of MIDP vs. ODP. Recent international surveys, however, revealed that surgeons have concerns about the oncological outcomes of MIDP for PDAC.

Methods: This is a pan-European propensity score matched study including patients who underwent MIDP (laparoscopic or robot-assisted) or ODP for PDAC between January 1, 2007 and July 1, 2015. MIDP patients were matched to ODP patients in a 1:1 ratio. Main outcomes were radical (R0) resection, lymph node retrieval, and survival.

Results: In total, 1212 patients were included from 34 centers in 11 countries. Of 356 (29%) MIDP patients, 340 could be matched. After matching, the MIDP conversion rate was 19% (n = 62). Median blood loss [200 mL (60–400) vs 300 mL (150–500), P = 0.001] and hospital stay [8 (6–12) vs 9 (7–14) days, P < 0.001] were lower after MIDP. Clavien-Dindo grade ≥3 complications (18% vs 21%, P = 0.431) and 90-day mortality (2% vs 3%, P > 0.99) were comparable for MIDP and ODP, respectively. R0 resection rate was higher (67% vs 58%, P = 0.019), whereas Gerota's fascia resection (31% vs 60%, P < 0.001) and lymph node retrieval [14 (8–22) vs 22 (14–31), P< 0.001] were lower after MIDP. Median overall survival was 28 [95% confidence interval (CI), 22–34] versus 31 (95% CI, 26–36) months (P = 0.929).

Conclusions: Comparable survival was seen after MIDP and ODP for PDAC, but the opposing differences in R0 resection rate, resection of Gerota's fascia, and lymph node retrieval strengthen the need for a randomized trial to confirm the oncological safety of MIDP.

Ort, förlag, år, upplaga, sidor
Lippincott Williams & Wilkins, 2019. Vol. 269, nr 1, s. 10-17
Nyckelord [en]
distal pancreatectomy; laparoscopic; left pancreatectomy; minimally invasive; robot-assisted
Nationell ämneskategori
Kirurgi
Identifikatorer
URN: urn:nbn:se:liu:diva-157572DOI: 10.1097/SLA.0000000000002561ISI: 000467455200021PubMedID: 29099399Scopus ID: 2-s2.0-85058902880OAI: oai:DiVA.org:liu-157572DiVA, id: diva2:1328640
Tillgänglig från: 2019-06-22 Skapad: 2019-06-22 Senast uppdaterad: 2019-06-24Bibliografiskt granskad

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Björnsson, BergthorSandström, Per
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Avdelningen för Kirurgi, Ortopedi och OnkologiMedicinska fakultetenKirurgiska kliniken US
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