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Economic burden of moderate to severe irritable bowel syndrome with constipation in six European countries
University Hospital Gasthuisberg, Leuven, Belgium; University of Leuven, Herestraat 49, Leuven, 3000, Belgium.
University Hospital S.Orsola, Bologna, Italy.
Centro Médico Teknon, Barcelona, Spain.
County Durham and Darlington NHS Trust, Durham, United Kingdom.
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2019 (engelsk)Inngår i: BMC Gastroenterology, ISSN 1471-230X, E-ISSN 1471-230X, Vol. 19, nr 1, artikkel-id 69Artikkel i tidsskrift (Fagfellevurdert) Published
Abstract [en]

Background: Irritable bowel syndrome with predominant constipation (IBS-C) is a complex disorder with gastrointestinal and nervous system components. The study aim was to assess the economic burden of moderate to severe IBS-C in six European countries (France, Germany, Italy, Spain, Sweden and the UK). Methods: An observational, one year retrospective-prospective (6 months each) study of patients diagnosed in the last five years with IBS-C (Rome III criteria) and moderate to severe disease at inclusion (IBS Symptom Severity Scale score = 175). The primary objective was to assess the direct cost to European healthcare systems. Results: Five hundred twenty-five patients were included, 60% (range: 43.1-78.8%) suffered from severe IBS-C. During follow-up 11.1-24.0% of patients had a hospitalisation/emergency room (ER) visit, median stay range: 1.5-12.0 days and 41.1-90.4% took prescription drugs for IBS-C. 21.4-50.8% of employed patients took sick leave (mean: 11.6-64.1 days). The mean annual direct cost to the healthcare systems was €937.1- €2108.0. The total direct cost (combined costs to healthcare systems and patient) for IBS-C was €1421.7-€2487.1. Conclusions: IBS-C is not a life-threatening condition; however, it has large impact on healthcare systems and society. Direct and indirect costs for moderate to severe IBS-C were high with the largest direct cost driver being hospitalisations/ER visits. © 2019 The Author(s).

sted, utgiver, år, opplag, sider
BioMed Central Ltd. , 2019. Vol. 19, nr 1, artikkel-id 69
Emneord [en]
Economic analysis; Europe; Healthcare resource utilisation; IBS; IBS-C
HSV kategori
Identifikatorer
URN: urn:nbn:se:liu:diva-158060DOI: 10.1186/s12876-019-0985-1ISI: 000467407000001PubMedID: 31064345Scopus ID: 2-s2.0-85065501524OAI: oai:DiVA.org:liu-158060DiVA, id: diva2:1329142
Merknad

Funding agencies:This study and all data analyses were funded in full by Almirall, S.A. The preparation of this paper was funded by Almirall, S.A and Allergan International.

Tilgjengelig fra: 2019-06-24 Laget: 2019-06-24 Sist oppdatert: 2019-11-04

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