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Fluid volume kinetics of 20% albumin
Sodertalje Hosp, Sweden; Karolinska Inst, Sweden.
Linköpings universitet, Institutionen för klinisk och experimentell medicin, Avdelningen för Kirurgi, Ortopedi och Onkologi. Linköpings universitet, Medicinska fakulteten.
Karolinska Univ Hosp, Sweden.
Linköpings universitet, Institutionen för medicin och hälsa, Avdelningen för läkemedelsforskning. Linköpings universitet, Medicinska fakulteten. Region Östergötland, Sinnescentrum, Anestesi- och intensivvårdskliniken US (ANOPIVA).
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2019 (Engelska)Ingår i: British Journal of Clinical Pharmacology, ISSN 0306-5251, E-ISSN 1365-2125, Vol. 85, nr 6, s. 1303-1311Artikel i tidskrift (Refereegranskat) Published
Abstract [en]

Aims A population kinetic model was developed for the body fluid shifts occurring when 20% albumin is given by intravenous infusion. The aim was to study whether its efficacy to expand the plasma volume is impaired after major surgery. Methods An intravenous infusion of 3 mL/kg 20% albumin over 30 minutes was given to 15 volunteers and to 15 patients on the 1(st) day after major open abdominal surgery. Blood samples and urine were collected during 5 hours. Mixed-effect modelling software was used to develop a fluid volume kinetic model, using blood haemoglobin and urine excretion the estimate body fluid shifts, to which individual-specific covariates were added in sequence. Results The rise in plasma albumin expanded the plasma volume in excess of the infused volume by relocating noncirculating fluid (rate constant k(21)), but it also increased losses of fluid from the kinetic system (k(b)). The balance between k(21) and k(b) maintained the rise in plasma albumin and plasma volume at a virtual steady-state for almost 2 hours. The rate constant for urinary excretion (k(10)) was slightly reduced by the preceding surgery, by a marked rise in plasma albumin, and by a high preinfusion urinary concentration of creatinine. The arterial pressure, body weight, and plasma concentrations of C-reactive protein and shedding products of the endothelial glycocalyx layer (syndecan-1, heparan sulfate, and hyaluronic acid) did not serve as statistically significant covariates. Conclusions There were no clinically relevant differences in the kinetics of 20% albumin between postoperative patients and volunteers.

Ort, förlag, år, upplaga, sidor
WILEY , 2019. Vol. 85, nr 6, s. 1303-1311
Nyckelord [en]
albumin; fluid kinetics; heparan sulfate; hyperoncotic; syndecan-1
Nationell ämneskategori
Annan klinisk medicin
Identifikatorer
URN: urn:nbn:se:liu:diva-158059DOI: 10.1111/bcp.13897ISI: 000468974200027PubMedID: 30756411OAI: oai:DiVA.org:liu-158059DiVA, id: diva2:1329186
Anmärkning

Funding Agencies|Mats Kleberg Foundation

Tillgänglig från: 2019-06-24 Skapad: 2019-06-24 Senast uppdaterad: 2019-06-24

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Zdolsek, MarkusZdolsek, Joachim
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Avdelningen för Kirurgi, Ortopedi och OnkologiMedicinska fakultetenAvdelningen för läkemedelsforskningAnestesi- och intensivvårdskliniken US (ANOPIVA)
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British Journal of Clinical Pharmacology
Annan klinisk medicin

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