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Synthesis and characterization of novel thiophene based tetramers for potential detection of protein aggregates
Linköpings universitet, Institutionen för fysik, kemi och biologi, Kemi.
2019 (engelsk)Independent thesis Advanced level (degree of Master (Two Years)), 40 poäng / 60 hpOppgave
Abstract [en]

Alzheimer’s disease is a big problem in the elderly population. An important tool in gaining insight in this disease are staining studies using different probes. Conjugated oligothiophenes have shown promising properties as probes and in this thesis new potential probes have been made.

Three new tetrameric probes have been synthesized, consisting of three thiophene units and one aromatic heterocycle moiety. The aromatic heterocycles used were BTD, pyridine and indole. The synthesis method involved Suzuki cross coupling, bromination with NBS and iridium catalyst borylation. The BTD and pyridine containing probes were tested in staining experiments and the pyridine probe showed promising results.

sted, utgiver, år, opplag, sider
2019. , s. 25
Emneord [en]
Organic chemistry, synthesis, oligothiophenes, Alzheimer’s Disease, Suzuki cross coupling, bromination
HSV kategori
Identifikatorer
URN: urn:nbn:se:liu:diva-157701ISRN: LITH-IFM-A-EX—19/3624--SEOAI: oai:DiVA.org:liu-157701DiVA, id: diva2:1331098
Fag / kurs
Chemistry
Presentation
2019-06-11, 09:45 (engelsk)
Veileder
Examiner
Tilgjengelig fra: 2019-06-27 Laget: 2019-06-26 Sist oppdatert: 2019-06-27bibliografisk kontrollert

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