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Liver R2*is affected by both iron and fat: A dual biopsy-validated study of chronic liver disease
Linköpings universitet, Institutionen för medicin och hälsa, Avdelningen för radiologiska vetenskaper. Linköpings universitet, Medicinska fakulteten.
Linköpings universitet, Institutionen för medicin och hälsa, Avdelningen för kardiovaskulär medicin. Linköpings universitet, Medicinska fakulteten. Region Östergötland, Hjärt- och Medicincentrum, Magtarmmedicinska kliniken.
Linköpings universitet, Institutionen för medicin och hälsa, Avdelningen för radiologiska vetenskaper. Linköpings universitet, Medicinska fakulteten. Region Östergötland, Diagnostikcentrum, Röntgenkliniken i Linköping. Linköpings universitet, Centrum för medicinsk bildvetenskap och visualisering, CMIV.ORCID-id: 0000-0002-4111-1693
Linköpings universitet, Institutionen för medicin och hälsa, Avdelningen för radiologiska vetenskaper. Linköpings universitet, Medicinska fakulteten. Region Östergötland, Centrum för kirurgi, ortopedi och cancervård, Radiofysikavdelningen US. Linköpings universitet, Centrum för medicinsk bildvetenskap och visualisering, CMIV.ORCID-id: 0000-0003-4630-6550
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2019 (engelsk)Inngår i: Journal of Magnetic Resonance Imaging, ISSN 1053-1807, E-ISSN 1522-2586, Vol. 50, nr 1, s. 325-333Artikkel i tidsskrift (Fagfellevurdert) Published
Abstract [en]

Background Liver iron content (LIC) in chronic liver disease (CLD) is currently determined by performing an invasive liver biopsy. MRI using R2* relaxometry is a noninvasive alternative for estimating LIC. Fat accumulation in the liver, or proton density fat fraction (PDFF), may be a possible confounder of R2* measurements. Previous studies of the effect of PDFF on R2* have not used quantitative LIC measurement. Purpose To assess the associations between R2*, LIC, PDFF, and liver histology in patients with suspected CLD. Study Type Prospective. Population Eighty-one patients with suspected CLD. Field Strength/Sequence 1.5 T. Multiecho turbo field echo to quantify R2*. PRESS MRS to quantify PDFF. Assessment Each patient underwent an MR examination, followed by two needle biopsies immediately following the MR examination. The first biopsy was used for conventional histological assessment of LIC, whereas the second biopsy was used to quantitatively measure LIC using mass spectrometry. R2* was correlated with both LIC and PDFF. A correction for the influence of fat on R2* was calculated. Statistical Tests Pearson correlation, linear regression, and area under the receiver operating curve. Results There was a positive linear correlation between R2* and PDFF (R = 0.69), after removing data from patients with elevated iron levels, as defined by LIC. R2*, corrected for PDFF, was the best method for identifying patients with elevated iron levels, with a correlation of R = 0.87 and a sensitivity and specificity of 87.5% and 98.6%, respectively. Data Conclusion PDFF increases R2*. Technical Efficacy: Stage 2 J. Magn. Reson. Imaging 2019;50:325-333.

sted, utgiver, år, opplag, sider
WILEY , 2019. Vol. 50, nr 1, s. 325-333
Emneord [en]
liver iron content; liver fat; R2*; PDFF; iron overload
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Identifikatorer
URN: urn:nbn:se:liu:diva-158842DOI: 10.1002/jmri.26601ISI: 000471831600033PubMedID: 30637926OAI: oai:DiVA.org:liu-158842DiVA, id: diva2:1337519
Merknad

Funding Agencies|Region Ostergotland; Medical Research council of Southeast Sweden [FORSS #12621]; Swedish Research Council [VR/NT #2014-6157, VR/MH, #2007-2884]; Forskningsradet i Sydostra Sverige; Linkoping University; Linkoping University Hospital Research Foundations; Vinnova [#2013-01314]; Vetenskapsradet

Tilgjengelig fra: 2019-07-15 Laget: 2019-07-15 Sist oppdatert: 2019-09-19

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Fulltekst tilgjengelig fra 2020-09-13 14:26
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Karlsson, MarkusEkstedt, MattiasDahlström, NilsForsgren, MikaelIgnatova, SimoneNorén, BengtDahlqvist Leinhard, OlofKechagias, StergiosLundberg, Peter
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