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A repertoire of biomedical applications of noble metal nanoparticles
Linköping University, Department of Clinical and Experimental Medicine, Division of Clinical Chemistry. Linköping University, Faculty of Medicine and Health Sciences.
Univ Cambridge, England.
Indian Inst Technol Guwahati, India.
Hacettepe Univ, Turkey.
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2019 (English)In: Chemical Communications, ISSN 1359-7345, E-ISSN 1364-548X, Vol. 55, no 49, p. 6964-6996Article, review/survey (Refereed) Published
Abstract [en]

Noble metals comprise any of several metallic chemical elements that are outstandingly resistant to corrosion and oxidation, even at elevated temperatures. This group is not strictly defined, but the tentative list includes ruthenium, rhodium, palladium, silver, osmium, iridium, platinum and gold, in order of atomic number. The emerging properties of noble metal nanoparticles are attracting huge interest from the translational scientific community and have led to an unprecedented expansion of research and exploration of applications in biotechnology and biomedicine. Noble metal nanomaterials can be synthesised both by top-down and bottom up approaches, as well as via organism-assisted routes, and subsequently modified appropriately for the field of use. Nanoscale analogues of gold, silver, platinum, and palladium in particular, have gained primary importance owing to their excellent intrinsic properties and diversity of applications; they offer unique functional attributes, which are quite unlike the bulk material. Modulation of noble metal nanoparticles in terms of size, shape and surface functionalisation has endowed them with unusual capabilities and manipulation at the chemical level, which can lead to changes in their electrical, chemical, optical, spectral and other intrinsic properties. Such flexibility in multi-functionalisation delivers Ockhams razor to applied biomedical science. In this feature article, we highlight recent advances in the adaptation of noble metal nanomaterials and their biomedical applications in therapeutics, diagnostics and sensing.

Place, publisher, year, edition, pages
Royal Society of Chemistry, 2019. Vol. 55, no 49, p. 6964-6996
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URN: urn:nbn:se:liu:diva-158861DOI: 10.1039/c9cc01741kISI: 000471721700001PubMedID: 31140997Scopus ID: 2-s2.0-85067297304OAI: oai:DiVA.org:liu-158861DiVA, id: diva2:1337602
Note

Funding Agencies|Swedish Research Council [VR 2015-04434 DIABETSENS]; Mucosal Infection and Inflammation Center (MIIC), Linkoping University, Sweden; Linkoping University, Sweden; EU H2020 Marie Sklodowska-Curie Individual Fellowship from European Commission [706694]; SERB, India [EMR/2016/000857]; UKIERI, UK [DST/INT/UK/P-119/2016]

Available from: 2019-07-16 Created: 2019-07-16 Last updated: 2019-08-29Bibliographically approved

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Azharuddin, MohammadPatra, Hirak Kumar

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