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Rational Nanotoolbox with Theranostic Potential for Medicated Pro-Regenerative Corneal Implants
Linköping University, Department of Clinical and Experimental Medicine, Division of Cell Biology. Linköping University, Faculty of Medicine and Health Sciences. Department of Chemical Engineering and Biotechnology, Cambridge University, Cambridge, UK; Wolfson College, University of Cambridge, Cambridge, UK.ORCID iD: 0000-0002-6142-5489
Linköping University, Department of Clinical and Experimental Medicine, Division of Clinical Chemistry. Linköping University, Faculty of Medicine and Health Sciences.
Linköping University, Department of Clinical and Experimental Medicine, Division of Cell Biology. Linköping University, Faculty of Medicine and Health Sciences. Massachusetts Eye and Ear and Schepens Eye Research Institute, Department of Ophthalmology, Harvard Medical School, Boston, USA.
Linköping University, Department of Clinical and Experimental Medicine, Division of Neuro and Inflammation Science. Linköping University, Faculty of Medicine and Health Sciences.
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2019 (English)In: Advanced Functional Materials, ISSN 1616-301X, E-ISSN 1616-3028, article id 1903760Article in journal (Refereed) Epub ahead of print
Abstract [en]

Cornea diseases are a leading cause of blindness and the disease burden is exacerbated by the increasing shortage around the world for cadaveric donor corneas. Despite the advances in the field of regenerative medicine, successful transplantation of laboratory‐made artificial corneas is not fully realized in clinical practice. The causes of failure of such artificial corneal implants are multifactorial and include latent infections from viruses and other microbes, enzyme overexpression, implant degradation, extrusion or delayed epithelial regeneration. Therefore, there is an urgent unmet need for developing customized corneal implants to suit the host environment and counter the effects of inflammation or infection, which are able to track early signs of implant failure in situ. This work reports a nanotoolbox comprising tools for protection from infection, promotion of regeneration, and noninvasive monitoring of the in situ corneal environment. These nanosystems can be incorporated within pro‐regenerative biosynthetic implants, transforming them into theranostic devices, which are able to respond to biological changes following implantation.

Place, publisher, year, edition, pages
John Wiley & Sons, 2019. article id 1903760
Keywords [en]
herpes simplex virus type 1 (HSV-1), magnetic resonance imaging (MRI), premedicated cornea implants, pro-regeneration, theranostics
National Category
Microbiology in the medical area
Identifiers
URN: urn:nbn:se:liu:diva-159097DOI: 10.1002/adfm.201903760ISI: 000476281800001Scopus ID: 2-s2.0-85069940064OAI: oai:DiVA.org:liu-159097DiVA, id: diva2:1338756
Note

Funding agencies: EU H2020 Marie Sklodowska-Curie Individual Fellowship [706694]; MIIC Strategic Postdoc Grant; MIIC Seed Grant at Linkoping University (LiU), Sweden

Available from: 2019-07-24 Created: 2019-07-24 Last updated: 2019-08-23Bibliographically approved

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The full text will be freely available from 2020-07-15 00:01
Available from 2020-07-15 00:01

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Patra, Hirak KumarAzharuddin, MohammadIslam, Mohammad MirazulPapapavlou, GeorgiaRomu, ThobiasJafari, Mohammad JavadHinkula, Jorma

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Patra, Hirak KumarAzharuddin, MohammadIslam, Mohammad MirazulPapapavlou, GeorgiaDeb, SuryyaniRomu, ThobiasJafari, Mohammad JavadHinkula, Jorma
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Division of Cell BiologyFaculty of Medicine and Health SciencesDivision of Clinical ChemistryDivision of Neuro and Inflammation ScienceDivision of Microbiology and Molecular MedicineFaculty of Science & EngineeringCenter for Medical Image Science and Visualization (CMIV)Molecular PhysicsDivision of Hematopoiesis and Developmental Biology
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Microbiology in the medical area

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