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Rational Nanotoolbox with Theranostic Potential for Medicated Pro-Regenerative Corneal Implants
Linköpings universitet, Institutionen för klinisk och experimentell medicin, Avdelningen för cellbiologi. Linköpings universitet, Medicinska fakulteten. Department of Chemical Engineering and Biotechnology, Cambridge University, Cambridge, UK; Wolfson College, University of Cambridge, Cambridge, UK.ORCID-id: 0000-0002-6142-5489
Linköpings universitet, Institutionen för klinisk och experimentell medicin, Avdelningen för klinisk kemi. Linköpings universitet, Medicinska fakulteten.
Linköpings universitet, Institutionen för klinisk och experimentell medicin, Avdelningen för cellbiologi. Linköpings universitet, Medicinska fakulteten. Massachusetts Eye and Ear and Schepens Eye Research Institute, Department of Ophthalmology, Harvard Medical School, Boston, USA.
Linköpings universitet, Institutionen för klinisk och experimentell medicin, Avdelningen för neuro- och inflammationsvetenskap. Linköpings universitet, Medicinska fakulteten.
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2019 (engelsk)Inngår i: Advanced Functional Materials, ISSN 1616-301X, E-ISSN 1616-3028, artikkel-id 1903760Artikkel i tidsskrift (Fagfellevurdert) Epub ahead of print
Abstract [en]

Cornea diseases are a leading cause of blindness and the disease burden is exacerbated by the increasing shortage around the world for cadaveric donor corneas. Despite the advances in the field of regenerative medicine, successful transplantation of laboratory‐made artificial corneas is not fully realized in clinical practice. The causes of failure of such artificial corneal implants are multifactorial and include latent infections from viruses and other microbes, enzyme overexpression, implant degradation, extrusion or delayed epithelial regeneration. Therefore, there is an urgent unmet need for developing customized corneal implants to suit the host environment and counter the effects of inflammation or infection, which are able to track early signs of implant failure in situ. This work reports a nanotoolbox comprising tools for protection from infection, promotion of regeneration, and noninvasive monitoring of the in situ corneal environment. These nanosystems can be incorporated within pro‐regenerative biosynthetic implants, transforming them into theranostic devices, which are able to respond to biological changes following implantation.

sted, utgiver, år, opplag, sider
John Wiley & Sons, 2019. artikkel-id 1903760
Emneord [en]
herpes simplex virus type 1 (HSV-1), magnetic resonance imaging (MRI), premedicated cornea implants, pro-regeneration, theranostics
HSV kategori
Identifikatorer
URN: urn:nbn:se:liu:diva-159097DOI: 10.1002/adfm.201903760ISI: 000476281800001Scopus ID: 2-s2.0-85069940064OAI: oai:DiVA.org:liu-159097DiVA, id: diva2:1338756
Merknad

Funding agencies: EU H2020 Marie Sklodowska-Curie Individual Fellowship [706694]; MIIC Strategic Postdoc Grant; MIIC Seed Grant at Linkoping University (LiU), Sweden

Tilgjengelig fra: 2019-07-24 Laget: 2019-07-24 Sist oppdatert: 2019-11-13bibliografisk kontrollert

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Fulltekst tilgjengelig fra 2020-07-15 00:01
Tilgjengelig fra 2020-07-15 00:01

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Patra, Hirak KumarAzharuddin, MohammadIslam, Mohammad MirazulPapapavlou, GeorgiaRomu, ThobiasJafari, Mohammad JavadHinkula, Jorma

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Patra, Hirak KumarAzharuddin, MohammadIslam, Mohammad MirazulPapapavlou, GeorgiaDeb, SuryyaniRomu, ThobiasJafari, Mohammad JavadHinkula, Jorma
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