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Gender difference and genetic variance in lipoprotein receptor-related protein 1 is associated with mortality
Linköping University, Department of Medical and Health Sciences, Division of Cardiovascular Medicine. Linköping University, Faculty of Medicine and Health Sciences. Region Östergötland, Heart and Medicine Center, Department of Cardiology in Linköping.
Linköping University, Department of Medical and Health Sciences, Division of Drug Research. Linköping University, Faculty of Medicine and Health Sciences. Uppsala Univ, Sweden.
2019 (English)In: BIOMEDICAL REPORTS, ISSN 2049-9434, Vol. 11, no 1Article in journal (Refereed) Published
Abstract [en]

Cardiovascular diseases are an important health resource problem and studies have shown a genetic association between single nucleotide polymorphisms (SNPs) and cardiovascular diseases. According to the literature, lipoprotein receptor-related protein 1 (LRP1) is associated with coronary artery disease. The aim of the present study was to evaluate a possible association between different genotypes of LRP1 and all-cause and cardiovascular mortality from a gender perspective. In the present study, 489 elderly community-living people were invited to participate. Clinical examination, echocardiography and blood sampling including SNP analyses of LRP1 (rs1466535) were performed, including the T/T, C/T and C/C genotypes, and the participants were followed for 6.7 years. During the follow-up period, 116 (24%) all-cause and 75 (15%) cardiovascular deaths were registered. In the female population, the LRP1 of the T/T or C/T genotype exhibited a 5.6-fold increased risk of cardiovascular mortality and a 2.8-fold increased risk of all-cause mortality compared with the C/C genotype. No such genotype differences could be seen in the male population. Gender differences could be seen regarding the risk of mortality in the different genotypes. Females with the LRP1 T/T or C/T genotypes exhibited a significantly increased risk of both all-cause and cardiovascular mortality compared with the C/C genotypes. Therefore, more individualized cardiovascular prevention and treatment should be prioritized. However, since this was a small study, the observations should only be regarded as hypothesis-generating.

Place, publisher, year, edition, pages
SPANDIDOS PUBL LTD , 2019. Vol. 11, no 1
Keywords [en]
low-density lipoprotein receptor-related protein 1; genotypes; elderly; genders; mortality
National Category
Geriatrics
Identifiers
URN: urn:nbn:se:liu:diva-159152DOI: 10.3892/br.2019.1217ISI: 000474635900003PubMedID: 31258899OAI: oai:DiVA.org:liu-159152DiVA, id: diva2:1339653
Note

Funding Agencies|County Council of Ostergotland, University of Linkoping, Linkoping, Sweden; Swedish Heart and Lung Foundation

Available from: 2019-07-30 Created: 2019-07-30 Last updated: 2019-07-30

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Division of Cardiovascular MedicineFaculty of Medicine and Health SciencesDepartment of Cardiology in LinköpingDivision of Drug Research
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