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Tumor-derived exosomes: Implication in angiogenesis and antiangiogenesis cancer therapy
Tabriz Univ Med Sci, Iran.
Kermanshah Univ Med Sci, Iran.
Kermanshah Univ Med Sci, Iran.
Tabriz Univ Med Sci, Iran.
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2019 (English)In: Journal of Cellular Physiology, ISSN 0021-9541, E-ISSN 1097-4652, Vol. 234, no 10, p. 16885-16903Article, review/survey (Refereed) Published
Abstract [en]

Tumor cells utilize different strategies to communicate with neighboring tissues for facilitating tumor progression and invasion, one of these strategies has been shown to be the release of exosomes. Exosomes are small nanovesicles secreted by all kind of cells in the body, especially cancer cells, and mediate cell to cell communications. Exosomes play an important role in cancer invasiveness by harboring various cargoes that could accelerate angiogenesis. Here first, we will present an overview of exosomes, their biology, and their function in the body. Then, we will focus on exosomes derived from tumor cells as tumor angiogenesis mediators with a particular emphasis on the underlying mechanisms in various cancer origins. Also, exosomes derived from stem cells and tumor-associated macrophages will be discussed in this regard. Finally, we will discuss the novel therapeutic strategies of exosomes as drug delivery vehicles against angiogenesis.

Place, publisher, year, edition, pages
WILEY , 2019. Vol. 234, no 10, p. 16885-16903
Keywords [en]
angiogenesis; cancer therapy; exosomes; extracellular vesicles; tumor
National Category
Cell and Molecular Biology
Identifiers
URN: urn:nbn:se:liu:diva-159119DOI: 10.1002/jcp.28374ISI: 000474688200017PubMedID: 30793767OAI: oai:DiVA.org:liu-159119DiVA, id: diva2:1339684
Available from: 2019-07-30 Created: 2019-07-30 Last updated: 2019-07-30

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