liu.seSearch for publications in DiVA
Change search
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • harvard1
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • oxford
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf
Patch testing children with aluminium chloride hexahydrate in petrolatum: A review and a recommendation
Univ Gothenburg, Sweden.
Univ Gothenburg, Sweden.
Linköping University, Department of Clinical and Experimental Medicine, Division of Cell Biology. Linköping University, Faculty of Medicine and Health Sciences. Region Östergötland, Heart and Medicine Center, Department of Dermatology and Venerology.ORCID iD: 0000-0001-8336-9767
Region Östergötland, Heart and Medicine Center, Allergy Center.
Show others and affiliations
2019 (English)In: Contact Dermatitis, ISSN 0105-1873, E-ISSN 1600-0536, Vol. 81, no 2, p. 81-88Article, review/survey (Refereed) Published
Abstract [en]

Background: According to studies on adults, patch testing with aluminium chloride hexahydrate 2% pet. is insufficient to detect aluminium allergy, and a 10% preparation is recommended. Other studies suggest that a 2% preparation is sufficient for testing children. Objectives: To review three previously published Swedish studies on patch testing children with aluminium chloride hexahydrate 2% pet. Patients/Methods: Altogether, 601 children with persistent itching subcutaneous nodules (granulomas) induced by aluminium-adsorbed vaccines were patch tested with aluminium chloride hexahydrate 2% pet. and metallic aluminium in (a) a pertussis vaccine trial, (b) clinical practice, and (ca) prospective study. Results: Overall, 459 children had positive reactions to the 2% pet. preparation. Another 10 reacted positively only to metallic aluminium. An extreme positive reaction (+++) was seen in 65% of children aged 1 to 2 years as compared with 22% of children aged 7 years. From 8 years onwards, extreme positive reactions were scarce. Conclusions: Aluminium chloride hexahydrate 2% pet. is sufficient to trace aluminium allergy in children. Small children are at risk of extreme reactions. We thus suggest that aluminium chloride hexahydrate 10% pet. should not be used routinely in children before the age of 7 to 8 years.

Place, publisher, year, edition, pages
WILEY , 2019. Vol. 81, no 2, p. 81-88
Keywords [en]
allergic contact dermatitis; aluminium; aluminium-adsorbed vaccines; children; itching subcutaneous granulomas; patch test
National Category
Dermatology and Venereal Diseases
Identifiers
URN: urn:nbn:se:liu:diva-159236DOI: 10.1111/cod.13303ISI: 000474290400001PubMedID: 31066081OAI: oai:DiVA.org:liu-159236DiVA, id: diva2:1340886
Available from: 2019-08-06 Created: 2019-08-06 Last updated: 2019-08-06

Open Access in DiVA

No full text in DiVA

Other links

Publisher's full textPubMed

Search in DiVA

By author/editor
Falk, LarsNyström Kronander, Ulla
By organisation
Division of Cell BiologyFaculty of Medicine and Health SciencesDepartment of Dermatology and VenerologyAllergy Center
In the same journal
Contact Dermatitis
Dermatology and Venereal Diseases

Search outside of DiVA

GoogleGoogle Scholar

doi
pubmed
urn-nbn

Altmetric score

doi
pubmed
urn-nbn
Total: 8 hits
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • harvard1
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • oxford
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf