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Biomarkers of endothelial injury in plasma are dependent on kidney function
Sodertalje Hosp, Sweden; Karolinska Inst Danderyds Hosp KIDS, Sweden.
Karolinska Univ Hosp, Sweden.
Karolinska Univ Hosp, Sweden.
Linköpings universitet, Institutionen för klinisk och experimentell medicin, Avdelningen för Kirurgi, Ortopedi och Onkologi. Linköpings universitet, Medicinska fakulteten.
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2019 (Engelska)Ingår i: Clinical hemorheology and microcirculation, ISSN 1386-0291, E-ISSN 1875-8622, Vol. 72, nr 2, s. 161-168Artikel i tidskrift (Refereegranskat) Published
Abstract [en]

BACKGROUND: Injury (shedding) of the endothelial glycocalyx layer, which alters local blood flow and microvascular permeability, is assessed by measuring components of this layer in circulating blood. The influence of renal function on their concentrations is unknown. METHODS: Plasma and urine concentrations of three shedding products (syndecan-1, hyaluronic acid, and heparan sulfate) and creatinine were measured over 5 hours in 15 healthy volunteers and 15 postoperative patients; this guaranteed a spread of kidney functions. Renal clearances were calculated. RESULTS: Low renal clearances of syndecan-1 (mean 3.5 mL/min) and hyaluronic acid (0.8 mL/min) correlated inversely with the 6-fold variability in the plasma concentrations of these substances (r = -0 . 45 and-0.49). Low creatinine clearance correlated inversely (r = -0.60) and plasma creatinine directly (r = 0.52) with the two-fold variability in heparan sulfate, which was the only shedding substance that also correlated with C-reactive protein (r= 0.51) and, therefore, showed higher concentrations after surgery. CONCLUSIONS: The present explorative study suggests that a 6-fold variability in the plasma concentrations of three commonly measured endothelial shedding products can be understood by the kidneys ability to excrete them. This finding has implications when interpreting results of studies where shedding is assessed.

Ort, förlag, år, upplaga, sidor
IOS PRESS , 2019. Vol. 72, nr 2, s. 161-168
Nyckelord [en]
Endothelial glycocalyx; syndecan-1; heparan sulfate; hyaluronic acid; kidney function; renal clearance
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Annan klinisk medicin
Identifikatorer
URN: urn:nbn:se:liu:diva-159740DOI: 10.3233/CH-180444ISI: 000479309800006PubMedID: 30714949OAI: oai:DiVA.org:liu-159740DiVA, id: diva2:1343850
Tillgänglig från: 2019-08-19 Skapad: 2019-08-19 Senast uppdaterad: 2019-08-19

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Zdolsek, MarkusZdolsek, Joachim
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Avdelningen för Kirurgi, Ortopedi och OnkologiMedicinska fakultetenAvdelningen för läkemedelsforskningAnestesi- och intensivvårdskliniken US (ANOPIVA)
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Clinical hemorheology and microcirculation
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