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Label free urea biosensor based on organic electrochemical transistors
Univ Modena and Reggio Emilia, Italy.
Linköping University, Department of Science and Technology, Laboratory of Organic Electronics. Linköping University, Faculty of Science & Engineering.
Linköping University, Department of Science and Technology. Linköping University, Faculty of Science & Engineering. RISE Acreo, Sweden.
Univ Modena and Reggio Emilia, Italy.
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2018 (English)In: FLEXIBLE AND PRINTED ELECTRONICS, ISSN 2058-8585, Vol. 3, no 2, article id 024001Article in journal (Refereed) Published
Abstract [en]

The quantification of urea is of the utmost importance not only in medical diagnosis, where it serves as a potential indicator of kidney and liver disfunction, but also in food safety and environmental control. Here, we describe a urea biosensor based on urease entrapped in a crosslinked gelatin hydrogel, deposited onto a fully printed PEDOT:PSS-based organic electrochemical transistor (OECT). The device response is based on the modulation of the channel conductivity by the ionic species produced upon urea hydrolysis catalyzed by the entrapped urease. The biosensor shows excellent reproducibility, a limit of detection as low as 1 mu M and a response time of a few minutes. The fabrication of the OECTs by screen-printing on flexible substrates ensures a significant reduction in manufacturing time and costs. The low dimensionality and operational voltages (0.5 V or below) of these devices contribute to make these enzymatic OECT-based biosensors as appealing candidates for high-throughput monitoring of urea levels at the point-of-care or in the field.

Place, publisher, year, edition, pages
IOP PUBLISHING LTD , 2018. Vol. 3, no 2, article id 024001
Keywords [en]
organic bioelectronics; urease; gelatin; OECT; screen-printing
National Category
Environmental Sciences
Identifiers
URN: urn:nbn:se:liu:diva-160143DOI: 10.1088/2058-8585/aac8a8ISI: 000435373100001OAI: oai:DiVA.org:liu-160143DiVA, id: diva2:1349348
Note

Funding Agencies|Swedish Foundation for Strategic Research [RIT15-0119]; BIORAPID project [643056]; Fondazione di Vignola

Available from: 2019-09-09 Created: 2019-09-09 Last updated: 2019-09-09

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Diacci, ChiaraTheuer, LorenzSimon, DanielBerggren, Magnus
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CiteExportLink to record
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Citation style
  • apa
  • harvard1
  • ieee
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  • Other style
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Language
  • de-DE
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  • Other locale
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Output format
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