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Synthesis of proteophenes that can be utilized as fluorescent ligands for biological targets
Linköping University, Department of Physics, Chemistry and Biology, Chemistry.
2019 (English)Independent thesis Advanced level (degree of Master (Two Years)), 40 credits / 60 HE creditsStudent thesis
Abstract [en]

Small fluorescent probes are important tools when studying protein aggregates involved in different neurodegenerative diseases, such as Alzheimer’s disease. Luminescent conjugated oligothiophenes have been developed and shown to be excellent ligands when studying morphology among amyloids, due to their conjugated thiophene backbone that provides them with unique photophysical properties. This kind of probes are being developed successively to enhance the specificity of their biological targets. In this project, luminescent conjugated oligothiophenes functionalized with amino acids, so called proteophenes, have been synthesized to investigate their optical properties. Since amino acids are chiral molecules, the possibility of induced chirality to the thiophene backbone was examined, as well as the proteophenes ability to work as amyloidospecific ligands for the study of protein aggregates. The synthesis of four different proteophenes are presented in this report, along with analysis results of their photophysical properties.

Place, publisher, year, edition, pages
2019. , p. 43
Keywords [en]
Fluorescent probes, Neuredegenerative diseases, Luminescent Conjugated Oligothiophenes, Protein misfolding, Aggregates, Amyloids, Alzheimer’s disease, Aβ-plaque
National Category
Organic Chemistry
Identifiers
URN: urn:nbn:se:liu:diva-160185ISRN: LITH-IFM-A-EX--19/3626--SEOAI: oai:DiVA.org:liu-160185DiVA, id: diva2:1349513
Subject / course
Chemistry
Supervisors
Examiners
Available from: 2019-09-09 Created: 2019-09-09 Last updated: 2019-09-09Bibliographically approved

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CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • harvard1
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • oxford
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf