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Effects of monoamine manipulations on the personality and gene expression of three-spined sticklebacks
Linköping University, Department of Physics, Chemistry and Biology, Biology. Linköping University, Faculty of Science & Engineering.
Linköping University, Department of Physics, Chemistry and Biology, Biology. Linköping University, Faculty of Science & Engineering.
Linköping University, Department of Physics, Chemistry and Biology, Biology. Linköping University, Faculty of Science & Engineering.
Linköping University, Department of Physics, Chemistry and Biology, Biology. Linköping University, Faculty of Science & Engineering.
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2019 (English)Data set
Physical description [en]

Raw data used for analyses in published manuscript: Robin N. Abbey-Lee, Anastasia Kreshchenko, Xavier Fernandez Sala, Irina Petkova and Hanne Løvlie. 2019 Effects of monoamine manipulations on the personality and gene expression of three-spined sticklebacks. Journal of Experimental Biology 222, jeb211888. doi:10.1242/jeb.211888

Abstract [en]

Among-individual behavioral differences (i.e. animal personality) are commonly observed across taxa, although the underlying, causal mechanisms of such differences are poorly understood. Animal personality has been implicated in correlations with physiological functions as well as affecting fitness-related traits. Variation in many aspects of monoamine systems, such as metabolite levels and gene polymorphisms, has been linked to behavioral variation. Therefore, here we investigated the potential role of monoamines in explaining individual variation in personality, using two common pharmaceuticals that respectively alter the levels of serotonin and dopamine in the brain: fluoxetine and ropinirole. We exposed three- spined sticklebacks, a species that shows animal personality, to either chemical alone or to a combination of the two chemicals, for 18 days. During the experiment, fish were assayed at four time points for the following personality traits: exploration, boldness, aggression and sociability. To quantify brain gene expression on short- and longer-term scales, fish were sampled at two time points. Our results show that monoamine manipulations influence fish behavior. Specifically, fish exposed to either fluoxetine or ropinirole were significantly bolder, and fish exposed to the two chemicals together tended to be bolder than control fish. Our monoamine manipulations did not alter the gene expression of monoamine or stress-associated neurotransmitter genes, but control, untreated fish showed covariation between gene expression and behavior. Specifically, exploration and boldness were predicted by genes in the dopaminergic, serotonergic and stress pathways, and sociability was predicted by genes in the dopaminergic and stress pathways. These results add further support to the links between monoaminergic systems and personality, and show that exposure to monoamines can causally alter animal personality.

Place, publisher, year
Cambridge, 2019.
Keywords [en]
animal behavior, cocktail effects, dopamine, ecotoxicology, fish, serotonin
National Category
Behavioral Sciences Biology
Identifiers
URN: urn:nbn:se:liu:diva-160555OAI: oai:DiVA.org:liu-160555DiVA, id: diva2:1355301
Available from: 2019-09-27 Created: 2019-09-27 Last updated: 2019-12-05Bibliographically approved

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Raw Data(93 kB)44 downloadsDescription of content
File information
File name DATASET01.xlsxFile size 93 kBChecksum SHA-512Description All data for analyses and figures in the manuscript.
6b271ba73cf53eb673774111c799c3fcaad3ee66dc140ef73e482c81bcfcd6316ea156bfa0d48f2061ff86c621bcb03380d301eb90441b048c366ad1e3cd6932
Type datasetMimetype application/vnd.openxmlformats-officedocument.spreadsheetml.sheet

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Abbey-Lee, Robin N.Petkova, IrinaLøvlie, Hanne

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Abbey-Lee, Robin N.Kreshchenko, AnastasiaFernandez Sala, XavierPetkova, IrinaLøvlie, Hanne
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BiologyFaculty of Science & Engineering
Behavioral Sciences Biology
Abbey-Lee, R. N., Kreshchenko, A., Fernandez Sala, X., Petkova, I. & Løvlie, H. (2019). Effects of monoamine manipulations on the personality and gene expression of three-spined sticklebacks. Journal of Experimental Biology, 222(20), Article ID jeb211888.

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CiteExportLink to record
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Citation style
  • apa
  • harvard1
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  • modern-language-association-8th-edition
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