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Effects of monoamine manipulations on the personality and gene expression of three-spined sticklebacks
Linköping University, Department of Physics, Chemistry and Biology, Biology. Linköping University, Faculty of Science & Engineering.
Mechanical and Aeronautical Engineering Division L5, Department of Mechanical, Aerospace & Civil Engineering, Dalton Nuclear Institute, FSE Research Institutes,The University of Manchester, UK.
Linköping University, Department of Physics, Chemistry and Biology. Linköping University, Faculty of Science & Engineering.
Linköping University, Department of Physics, Chemistry and Biology, Biology. Linköping University, Faculty of Science & Engineering. School of Biological Sciences, Centre for Ecology,Evolution and Behaviour, Royal Holloway University of London, Egham UK.
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2019 (English)In: Journal of Experimental Biology, ISSN 0022-0949, E-ISSN 1477-9145, Vol. 222, no 20, article id jeb211888Article in journal (Refereed) Published
Abstract [en]

Among-individual behavioral differences (i.e. animal personality) are commonly observed across taxa, although the underlying, causal mechanisms of such differences are poorly understood. Animal personality has been correlated with physiological functions as well as fitness-related traits. Variation in many aspects of monoamine systems, such as metabolite levels and gene polymorphisms, has been linked to behavioral variation. Therefore, here we experimentally investigated the potential role of monoamines in explaining individual variation in personality, using two common pharmaceuticals that respectively alter the levels of serotonin and dopamine in the brain: fluoxetine and ropinirole. We exposed three-spined sticklebacks, a species that shows animal personality, to either chemical alone or to a combination of the two chemicals, for 18 days. During the experiment, fish were assayed at four time points for the following personality traits: exploration, boldness, aggression and sociability. To quantify brain gene expression on short- and longer-term scales, fish were sampled at two time points. Our results show that monoamine manipulations influence fish behavior. Specifically, fish exposed to either fluoxetine or ropinirole were significantly bolder, and fish exposed to the two chemicals together tended to be bolder than control fish. Our monoamine manipulations did not alter the gene expression of monoamine or stress-associated neurotransmitter genes, but control, untreated fish showed covariation between gene expression and behavior. Specifically, exploration and boldness were predicted by genes in the dopaminergic, serotonergic and stress pathways, and sociability was predicted by genes in the dopaminergic and stress pathways. These results add further support to the links between monoaminergic systems and personality, and show that exposure to monoamines can causally alter animal personality.

Place, publisher, year, edition, pages
The Company of Biologists Ltd , 2019. Vol. 222, no 20, article id jeb211888
Keywords [en]
Animal behavior, Cocktail effects, Dopamine, Ecotoxicology, Fish, Serotonin
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URN: urn:nbn:se:liu:diva-161075DOI: 10.1242/jeb.211888ISI: 000493796100019PubMedID: 31619541Scopus ID: 2-s2.0-85073434317OAI: oai:DiVA.org:liu-161075DiVA, id: diva2:1362574
Note

Funding agencies: Linkopings Universitet Centre for Systems Neurobiology; Royal Swedish Academy of Sciences (Kungl. Vetenskapsakademien); Royal Physiographic Society of Lund (Kungl. Fysiografiska Sallskapet i Lund); Langmanska Cultural Foundation (Langmanska Kulturfonden);

Available from: 2019-10-21 Created: 2019-10-21 Last updated: 2019-12-05Bibliographically approved

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Abbey-Lee, Robin N.Petkova, IrinaLøvlie, Hanne

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Abbey-Lee, Robin N.Fernandez Sala, XavierPetkova, IrinaLøvlie, Hanne
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BiologyFaculty of Science & EngineeringDepartment of Physics, Chemistry and Biology
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Journal of Experimental Biology
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Abbey-Lee, R. N., Kreshchenko, A., Fernandez Sala, X., Petkova, I. & Løvlie, H. (2019). Effects of monoamine manipulations on the personality and gene expression of three-spined sticklebacks. Cambridge

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