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Modulating Inflammation in Monocytes Using Capillary Fiber Organic Electronic Ion Pumps
Linköping University, Department of Science and Technology, Physics and Electronics. Linköping University, Faculty of Science & Engineering.
Linköping University, Department of Clinical and Experimental Medicine, Division of Microbiology, Infection and Inflammation. Linköping University, Faculty of Medicine and Health Sciences.
Linköping University, Department of Clinical and Experimental Medicine, Division of Microbiology, Infection and Inflammation. Linköping University, Faculty of Medicine and Health Sciences.ORCID iD: 0000-0001-9431-741X
Linköping University, Department of Science and Technology, Laboratory of Organic Electronics. Linköping University, Faculty of Science & Engineering.ORCID iD: 0000-0001-5154-0291
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2019 (English)In: Advanced Healthcare Materials, ISSN 2192-2640, E-ISSN 2192-2659, Vol. 8, no 19, article id 1900813Article in journal (Refereed) Published
Abstract [en]

An organic electronic ion pump (OEIP) delivers ions and drugs from a source, through a charge selective membrane, to a target upon an electric bias. Miniaturization of this technology is crucial and will provide several advantages, ranging from better spatiotemporal control of delivery to reduced invasiveness for implanted OEIPs. To miniaturize OEIPs, new configurations have been developed based on glass capillary fibers filled with an anion exchange membrane (AEM). Fiber capillary OEIPs can be easily implanted in proximity to targeted cells and tissues. Herein, the efficacy of such a fiber capillary OEIP for modulation of inflammation in human monocytes is demonstrated. The devices are located on inflammatory monocytes and local delivery of salicylic acid (SA) is initiated. Highly localized SA delivery results in a significant decrease in cytokine (tumor necrosis factor alpha and interleukin 6) levels after lipopolysaccharide stimulation. The findings-the first use of such capillary OEIPs in mammalian cells or systems-demonstrate the utility of the technology for optimizing transport and delivery of different therapeutic substances at low concentrations, with the benefit of local and controlled administration that limits the adverse effect of oral/systemic drug delivery.

Place, publisher, year, edition, pages
WILEY , 2019. Vol. 8, no 19, article id 1900813
Keywords [en]
bioelectronics; capillary fibers; cytokines; drug delivery; electrophoresis; inflammation; ion exchange membranes; iontronics; organic electronics
National Category
Biophysics
Identifiers
URN: urn:nbn:se:liu:diva-161161DOI: 10.1002/adhm.201900813ISI: 000486128400001PubMedID: 31502760OAI: oai:DiVA.org:liu-161161DiVA, id: diva2:1365745
Note

Funding Agencies|Swedish Foundation for Strategic ResearchSwedish Foundation for Strategic Research [RIT15-0119]; Advanced Functional Materials SFO-Center at Linkoping University; International Interdisciplinary Laboratory for Advanced Functional Materials, Linkopings Universitet; Onnesjo Foundation; Knut and Alice Wallenberg FoundationKnut & Alice Wallenberg Foundation

Available from: 2019-10-25 Created: 2019-10-25 Last updated: 2019-10-25

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Physics and ElectronicsFaculty of Science & EngineeringDivision of Microbiology, Infection and InflammationFaculty of Medicine and Health SciencesLaboratory of Organic Electronics
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