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Interleukin-1 reduces food intake and body weight in rat by acting in the arcuate hypothalamus
Univ Bordeaux, France.
Natl Inst Biol Stand and Controls, England.
Univ Bordeaux, France.
Univ Texas Houston, TX 77030 USA.
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2019 (Engelska)Ingår i: Brain, behavior, and immunity, ISSN 0889-1591, E-ISSN 1090-2139, Vol. 81, s. 560-573Artikel i tidskrift (Refereegranskat) Published
Abstract [en]

A reduction in food intake is commonly observed after bacterial infection, a phenomenon that can be reproduced by peripheral administration of Gram-negative bacterial lipopolysaccharide (LPS) or interleukin-lbeta (IL-1 beta), a pro-inflammatory cytokine released by LPS-activated macrophages. The arcuate nucleus of the hypothalamus (ARH) plays a major role in food intake regulation and expresses IL-1 type 1 receptor (IL-1R1) mRNA. In the present work, we tested the hypothesis that IL-1R1 expressing cells in the ARH mediate IL-1 beta and/or LPS-induced hypophagia in the rat. To do so, we developed an IL-1 beta-saporin conjugate, which eliminated IL-R1 expressing neurons in the hippocampus, and micro-injected it into the ARH prior to systemic IL-1 beta and LPS administration. ARH IL-1 beta-saporin injection resulted in loss of neuropeptide Y-containing cells and attenuated hypophagia and weight loss after intraperitoneal IL-1 beta, but not LPS, administration. In conclusion, the present study shows that ARH NPY-containing neurons express functional IL-1R1s that mediate peripheral IL-1 beta-, but not LPS-, induced hypophagia. Our present and previous findings indicate that the reduction of food intake after IL-1 beta and LPS are mediated by different neural pathways.

Ort, förlag, år, upplaga, sidor
ACADEMIC PRESS INC ELSEVIER SCIENCE , 2019. Vol. 81, s. 560-573
Nyckelord [en]
Interleukin-1; Lipopolysaccharide; Hypophagia; Arcuate nucleus; Neuropeptide Y
Nationell ämneskategori
Immunologi
Identifikatorer
URN: urn:nbn:se:liu:diva-160984DOI: 10.1016/j.bbi.2019.07.017ISI: 000488135800057PubMedID: 31310797OAI: oai:DiVA.org:liu-160984DiVA, id: diva2:1370179
Anmärkning

Funding Agencies|Swedish Research CouncilSwedish Research Council [07879]; Swedish Cancer Foundation [16/0572]; Swedish Brain Foundation

Tillgänglig från: 2019-11-14 Skapad: 2019-11-14 Senast uppdaterad: 2020-01-08

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Publikationen är tillgänglig i fulltext från 2020-07-13 13:53
Tillgänglig från 2020-07-13 13:53

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Blomqvist, Anders
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Avdelning för neurobiologiMedicinska fakulteten
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Brain, behavior, and immunity
Immunologi

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