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Effect of N-G-monomethyl l-arginine on microvascular blood flow and glucose metabolism after an oral glucose load
Linköpings universitet, Institutionen för klinisk och experimentell medicin, Avdelningen för Kirurgi, Ortopedi och Onkologi. Linköpings universitet, Medicinska fakulteten.
Linköpings universitet, Institutionen för klinisk och experimentell medicin, Avdelningen för Kirurgi, Ortopedi och Onkologi. Linköpings universitet, Medicinska fakulteten. Region Östergötland, Primärvårdscentrum, Vårdcentralen Åby.ORCID-id: 0000-0002-4245-7565
Linköpings universitet, Institutionen för klinisk och experimentell medicin, Avdelningen för Kirurgi, Ortopedi och Onkologi. Linköpings universitet, Medicinska fakulteten.
Linköpings universitet, Institutionen för klinisk och experimentell medicin, Avdelningen för Kirurgi, Ortopedi och Onkologi. Linköpings universitet, Medicinska fakulteten. Region Östergötland, Sinnescentrum, Hand- och plastikkirurgiska kliniken US.
2019 (engelsk)Inngår i: Microcirculation, ISSN 1073-9688, E-ISSN 1549-8719, artikkel-id e12597Artikkel i tidsskrift (Fagfellevurdert) Epub ahead of print
Abstract [en]

Objective The aim of this study was to investigate whether the effects on local blood flow and metabolic changes observed in the skin after an endogenous systemic increase in insulin are mediated by the endothelial nitric oxide pathway, by administering the nitric oxide synthase inhibitor N-G-monomethyl l-arginine using microdialysis. Methods Microdialysis catheters, perfused with N-G-monomethyl l-arginine and with a control solution, were inserted intracutaneously in 12 human subjects, who received an oral glucose load to induce a systemic hyperinsulinemia. During microdialysis, the local blood flow was measured by urea clearance and by laser speckle contrast imaging, and glucose metabolites were measured. Results After oral glucose intake, microvascular blood flow and glucose metabolism were both significantly suppressed in the N-G-monomethyl l-arginine catheter compared to the control catheter (urea clearance: P amp;lt; .006, glucose dialysate concentration: P amp;lt; .035). No significant effect of N-G-monomethyl l-arginine on microvascular blood flow was observed with laser speckle contrast imaging (P = .81). Conclusion Local delivery of N-G-monomethyl l-arginine to the skin by microdialysis reduces microvascular blood flow and glucose delivery in the skin after oral glucose intake, presumably by decreasing local insulin-mediated vasodilation.

sted, utgiver, år, opplag, sider
WILEY , 2019. artikkel-id e12597
Emneord [en]
insulin; l-NMMA; metabolism; microcirculation; microdialysis
HSV kategori
Identifikatorer
URN: urn:nbn:se:liu:diva-162323DOI: 10.1111/micc.12597ISI: 000494847400001PubMedID: 31628700OAI: oai:DiVA.org:liu-162323DiVA, id: diva2:1374034
Merknad

Funding Agencies|ALF grants, Region Ostergotland, Linkoping, Sweden

Tilgjengelig fra: 2019-11-28 Laget: 2019-11-28 Sist oppdatert: 2019-11-28

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Högstedt, AlexandraIredahl, FredrikTesselaar, ErikFarnebo, Simon
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