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Sedimentation rate and suPAR in relation to disease activity and mortality in patients with tuberculosis
Region Östergötland, Heart and Medicine Center, Department of Infectious Diseases.
Linköping University, Department of Clinical and Experimental Medicine, Division of Microbiology, Infection and Inflammation. Linköping University, Faculty of Medicine and Health Sciences. Region Östergötland, Heart and Medicine Center, Department of Infectious Diseases.
Univ Gondar, Ethiopia; Ethiopian Publ Hlth Inst, Ethiopia.
Linköping University, Department of Clinical and Experimental Medicine, Division of Surgery, Orthopedics and Oncology. Linköping University, Faculty of Medicine and Health Sciences.
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2019 (English)In: The International Journal of Tuberculosis and Lung Disease, ISSN 1027-3719, E-ISSN 1815-7920, Vol. 23, no 11, p. 1155-1161Article in journal (Refereed) Published
Abstract [en]

OBJECTIVE : To investigate how levels of the soluble urokinase plasminogen activator receptor (suPAR) and erythrocyte sedimentation rate (ESR) correlate with disease activity and prognosis in pulmonary tuberculosis (PTB). DESIGN: This was a retrospective analysis of patients with active PTB (n = 500) in Gondar, Ethiopia, for whom the suPAR (n = 301) and ESR (n = 330) were analysed at the start of treatment. Both biomarkers were available for 176 patients. Human immunodeficiency virus (HIV) status, chest X-ray (CXR) findings, classification according to the clinical TBscore and treatment outcome were all recorded. RESULTS : In a multivariable logistic regression analysis adjusted for age, sex and HIV status, surrogate markers of disease activity such as advanced CXR patterns correlated with increased levels of suPAR (adjusted OR [aOR] 8.24, Pamp;lt; 0.001) and of ESR (aOR 1.63, P = 0.030), whereas ESR only correlated significantly with a TBscore amp;gt;6 points. Increased levels of both suPAR and ESR were associated with unsuccessful treatment outcomes (aOR 2.93, P = 0.013; aOR 2.52, P = 0.025). The highest quartile of suPAR (aOR 13.3, P = 0.029) but not ESR levels correlated independently with increased mortality. CONCLUSION: SuPAR and ESR levels correlate with disease activity in PTB; however, the clinical role of these potentially prognostic biomarkers needs to be verified in prospective studies.

Place, publisher, year, edition, pages
INT UNION AGAINST TUBERCULOSIS LUNG DISEASE (I U A T L D) , 2019. Vol. 23, no 11, p. 1155-1161
Keywords [en]
chest X-ray; TBscore; HIV; outcome; biomarkers
National Category
Respiratory Medicine and Allergy
Identifiers
URN: urn:nbn:se:liu:diva-162541DOI: 10.5588/ijtld.18.0634ISI: 000496915300006PubMedID: 31718751OAI: oai:DiVA.org:liu-162541DiVA, id: diva2:1376303
Note

Funding Agencies|Swedish Research Council, Stockholm, SwedenSwedish Research Council [201602043]; Swedish Heart and Lung Foundation (Oscar II Jubilee Foundation), Stockholm, Sweden

Available from: 2019-12-09 Created: 2019-12-09 Last updated: 2020-04-29

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Schulman, H.Niward, KatarinaIdh, JonnaAxenram, P.Bornefall, AnnaForsgren, S.Jakobsson, J.Öhrling, C.Kron, M.Brudin, LarsPaues, JakobStendahl, OlleSchön, Thomas
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Department of Infectious DiseasesDivision of Microbiology, Infection and InflammationFaculty of Medicine and Health SciencesDivision of Surgery, Orthopedics and OncologyDepartment of Clinical and Experimental MedicineDivision of Cardiovascular Medicine
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