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Assessment of genetic and non-genetic risk factors for venous thromboembolism in glioblastoma - The predictive significance of B blood group
Linköping University, Faculty of Medicine and Health Sciences. Region Östergötland, Center for Diagnostics, Department of Clinical Chemistry. Linköping University, Department of Clinical and Experimental Medicine, Division of Clinical Chemistry.
Linköping University, Department of Clinical and Experimental Medicine, Division of Cell Biology. Linköping University, Faculty of Medicine and Health Sciences. Region Östergötland, Local Health Care Services in Central Östergötland, Närvårdskliniken.ORCID iD: 0000-0001-8410-4939
Linköping University, Department of Clinical and Experimental Medicine, Division of Cell Biology. Linköping University, Faculty of Medicine and Health Sciences.ORCID iD: 0000-0002-0244-759X
Linköping University, Department of Clinical and Experimental Medicine, Division of Surgery, Orthopedics and Oncology. Linköping University, Faculty of Medicine and Health Sciences.
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2019 (English)In: Thrombosis Research, ISSN 0049-3848, E-ISSN 1879-2472, Vol. 183, p. 136-142Article in journal (Refereed) Published
Abstract [en]

Introduction: Venous thromboembolism (VTE) is a common problem among patients with glioblastoma multi-forme (GBM) and with some other cancers. Here, we evaluated genetic and non-genetic potential risk factors for VTE among GBM patients. Materials and methods: A cohort of 139 patients treated with concomitant radiotherapy and temozolomide were included in the study. Next generation sequencing and genotyping approaches were applied to assess genetic risk factors in the haemostatic system. Clinical data including surgery, reoperation as well as blood group and patient information such as age and gender were available from patient records. Logistic regression analysis was performed to asses VTE risk. Results: In the study 47 patients (34%) were diagnosed for VTE during the course of their disease. When genetic and non-genetic potential risk factors were evaluated, only B blood group was found to be significantly associated with VTE incidence (odds ratio [OR] = 6.91; confidence interval [CI] = 2.19-24.14; P = 0.001). In contrast, A and O blood groups did not correlate with VTE risk. Frontal lobe tumor location also seemed to slightly increase VTE risk compared to other brain sites (OR = 3.14; CI = 1.1-10.7) although the significance level was at borderline (P = 0.05). Current study identified B blood group as the component in non-O blood groups that is responsible for increased VTE risk. Conclusion: In conclusion, these results suggest for the first time that B blood group is predictive for VTE incidence among patients with glioblastoma, information that may be potentially valuable when selecting GBM patients who are at risk for VTE for anticoagulant prophylaxis.

Place, publisher, year, edition, pages
PERGAMON-ELSEVIER SCIENCE LTD , 2019. Vol. 183, p. 136-142
Keywords [en]
ABO blood groups; Glioblastoma; Sequence analysis; DNA; Surgery; Tumor location; Venous thromboembolism
National Category
Cardiac and Cardiovascular Systems
Identifiers
URN: urn:nbn:se:liu:diva-162537DOI: 10.1016/j.thromres.2019.10.009ISI: 000497805700024PubMedID: 31677594OAI: oai:DiVA.org:liu-162537DiVA, id: diva2:1376489
Note

Funding Agencies|Medical Research Council of Southeast Sweden (FORSS); County Council of Region Ostergotland, Sweden

Available from: 2019-12-09 Created: 2019-12-09 Last updated: 2020-05-02

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The full text will be freely available from 2020-10-22 14:11
Available from 2020-10-22 14:11

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Malmström, AnnikaSöderkvist, PeterUppugunduri, Srinivas

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Heenkenda, Menikae KanchenaMalmström, AnnikaLysiak, MalgorzataMudaisi, MunilaMilos, PeterÅkesson, LisaSöderkvist, PeterUppugunduri, SrinivasOsman, Abdimajid
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Faculty of Medicine and Health SciencesDepartment of Clinical ChemistryDivision of Clinical ChemistryDivision of Cell BiologyNärvårdsklinikenDivision of Surgery, Orthopedics and OncologyDivision of Neuro and Inflammation ScienceDepartment of NeurosurgeryDepartment of Thematic StudiesFaculty of Arts and SciencesClinical geneticsRegional Cancer Center
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Thrombosis Research
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