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Primary treatment patterns and survival of cervical cancer in Sweden: A population-based Swedish Gynecologic Cancer Group Study
Lund Univ, Sweden.
Reg Canc Ctr West, Sweden; Sahlgrens Acad, Sweden.
Skane Univ Hosp, Sweden; Lund Univ, Sweden.
Karolinska Inst, Sweden.
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2019 (English)In: Gynecologic Oncology, ISSN 0090-8258, E-ISSN 1095-6859, Vol. 155, no 2, p. 229-236Article in journal (Refereed) Published
Abstract [en]

Objective: Survival in cervical cancer has improved little over the last decades. We aimed to elucidate primary treatment patterns and survival. Methods: Population-based study of patients included in the Swedish Quality Registry for Gynecologic Cancer diagnosed 2011-2015. Main outcome was 5-year relative survival (RS). Age-standardised RS (AS-RS) was estimated for the total cohort and for the pooled study population of squamous, adenosquamous-, adenocarcinoma. Results: Median follow-up time was 4.6 years. The study population consisted of 2141 patients; 97% of the 2212 patients in the total cohort and the 5-year AS-RS was 71% and 70%, respectively. RS stage IB1: surgery alone 95% vs. 72% for definitive chemoradiotherapy (CT-RT) (p amp;lt; 0.001). In stage IIA1 74% had CTRL, and 47% of operated patients received adjuvant (CT)-RT. RS stage IB2: surgically treated 81% (69% received adjuvant (CT)-RT) vs. 76% for (CT)-RT (p = 0.73). RS stage IIB: 77% for CT-RT + brachytherapy BT), 37% for RT + BT (p = 0.045) and 27% for RT-BT (p amp;lt; 0.001). Stages III-IVA; amp;lt;40% received CT-RT + BT, RS 45% vs. 18% for RT-BT (RR 4.1, p amp;lt; 0.001). RS stage IVB 7%. Conclusion: Primary treatment of cervical cancer in Sweden adhered to evidence-based standard of care. Areas of improvement include optimising treatment for stages III-IVA, and avoiding combining surgery and radiotherapy. (C) 2019 Elsevier Inc. All rights reserved.

Place, publisher, year, edition, pages
ACADEMIC PRESS INC ELSEVIER SCIENCE , 2019. Vol. 155, no 2, p. 229-236
Keywords [en]
Cervical cancer; Survival; Treatment; Surgery; Radiotherapy
National Category
Surgery
Identifiers
URN: urn:nbn:se:liu:diva-162535DOI: 10.1016/j.ygyno.2019.08.022ISI: 000497893600010PubMedID: 31477283OAI: oai:DiVA.org:liu-162535DiVA, id: diva2:1376493
Note

Funding Agencies|Swedish Cancer SocietySwedish Cancer Society

Available from: 2019-12-09 Created: 2019-12-09 Last updated: 2020-04-29

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Kjölhede, PrebenRosenberg, PerÅvall Lundqvist, Elisabeth
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Division of Children's and Women's healthFaculty of Medicine and Health SciencesDepartment of Gynaecology and Obstetrics in LinköpingDepartment of OncologyDivision of Surgery, Orthopedics and Oncology
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Gynecologic Oncology
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