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Miniaturized Ionic Polarization Diodes for Neurotransmitter Release at Synaptic Speeds
Linköping University, Department of Science and Technology, Laboratory of Organic Electronics. Linköping University, Faculty of Science & Engineering.
Linköping University, Department of Science and Technology, Physics and Electronics. Linköping University, Faculty of Science & Engineering.
Linköping University, Department of Science and Technology, Laboratory of Organic Electronics. Linköping University, Faculty of Science & Engineering.ORCID iD: 0000-0002-0302-226X
Linköping University, Department of Science and Technology, Laboratory of Organic Electronics. Linköping University, Faculty of Science & Engineering.ORCID iD: 0000-0001-5154-0291
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2019 (English)In: ADVANCED MATERIALS TECHNOLOGIES, ISSN 2365-709X, article id 1900750Article in journal (Refereed) Epub ahead of print
Abstract [en]

Current neural interfaces rely on electrical stimulation pulses to affect neural tissue. The development of a chemical delivery technology, which can stimulate neural tissue with the bodys own set of signaling molecules, would provide a new level of sophistication in neural interfaces. Such technology should ideally provide highly local chemical delivery points that operate at synaptic speed, something that is yet to be accomplished. Here, the development of a miniaturized ionic polarization diode that exhibits many of the desirable properties for a chemical neural interface technology is reported. The ionic diode shows proper diode rectification and the current switches from off to on in 50 mu s at physiologically relevant electrolyte concentrations. A device model is developed to explain the characteristics of the ionic diode in more detail. In combination with experimental data, the model predicts that the ionic polarization diode has a delivery delay of 5 ms to reach physiologically relevant neurotransmitter concentrations at subcellular spatial resolution. The model further predicts that delays of amp;lt;1 ms can be reached by further miniaturization of the diode geometry. Altogether, the results show that ionic polarization diodes are a promising building block for the next generation of chemical neural interfaces.

Place, publisher, year, edition, pages
WILEY , 2019. article id 1900750
Keywords [en]
bioelectronics; controlled release; ion diodes; iontronics; neurotransmitters
National Category
Bioinformatics (Computational Biology)
Identifiers
URN: urn:nbn:se:liu:diva-162499DOI: 10.1002/admt.201900750ISI: 000497801400001OAI: oai:DiVA.org:liu-162499DiVA, id: diva2:1379012
Note

Funding Agencies|Swedish Foundation for Strategic ResearchSwedish Foundation for Strategic Research; Knut and Alice Wallenberg foundationKnut & Alice Wallenberg Foundation; Swedish Government Strategic Research Area in Materials Science on Advanced Functional Materials at Linkoping University [2009-00971]

Available from: 2019-12-16 Created: 2019-12-16 Last updated: 2020-01-15

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The full text will be freely available from 2020-11-22 14:26
Available from 2020-11-22 14:26

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