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Drosophila Neuroblast Selection Is Gated by Notch, Snail, SoxB, and EMT Gene Interplay
Linköping University, Department of Clinical and Experimental Medicine, Division of Hematopoiesis and Developmental Biology. Linköping University, Faculty of Medicine and Health Sciences.
Linköping University, Department of Clinical and Experimental Medicine, Division of Hematopoiesis and Developmental Biology. Linköping University, Faculty of Medicine and Health Sciences.
Linköping University, Department of Clinical and Experimental Medicine, Division of Hematopoiesis and Developmental Biology. Linköping University, Faculty of Medicine and Health Sciences. Hosp Sick Children, Canada; Karolinska Inst, Sweden.ORCID iD: 0000-0002-2671-3645
Linköping University, Department of Clinical and Experimental Medicine, Division of Hematopoiesis and Developmental Biology. Linköping University, Faculty of Medicine and Health Sciences.ORCID iD: 0000-0001-7250-234x
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2019 (English)In: Cell reports, ISSN 2211-1247, E-ISSN 2211-1247, Vol. 29, no 11, p. 3636-3651.e3Article in journal (Refereed) Published
Abstract [en]

In the developing Drosophila central nervous system (CNS), neural progenitor (neuroblast [NB]) selection is gated by lateral inhibition, controlled by Notch signaling and proneural genes. However, proneural mutants still generate many NBs, indicating the existence of additional proneural genes. Moreover, recent studies reveal involvement of key epithelial-mesenchymal transition (EMT) genes in NB selection, but the regulatory interplay between Notch signaling and the EMT machinery is unclear. We find that SoxNeuro (SoxB family) and worniu (Snail family) are integrated with the Notch pathway, and constitute the missing proneural genes. Notch signaling, the proneural, SoxNeuro, and worniu genes regulate key EMT genes to orchestrate the NB selection process. Hence, we uncover an expanded lateral inhibition network for NB selection and demonstrate its link to key players in the EMT machinery. The evolutionary conservation of the genes involved suggests that the Notch-SoxB-Snail-EMT network may control neural progenitor selection in many other systems.

Place, publisher, year, edition, pages
Cambridge, United States: CELL PRESS , 2019. Vol. 29, no 11, p. 3636-3651.e3
National Category
Medical Biotechnology (with a focus on Cell Biology (including Stem Cell Biology), Molecular Biology, Microbiology, Biochemistry or Biopharmacy)
Identifiers
URN: urn:nbn:se:liu:diva-162946DOI: 10.1016/j.celrep.2019.11.038ISI: 000502113400023PubMedID: 31825841Scopus ID: 2-s2.0-85075991313OAI: oai:DiVA.org:liu-162946DiVA, id: diva2:1382360
Note

Funding Agencies|Swedish Research CouncilSwedish Research Council [621-2013-5258, 2017-04061]; Knut and Alice Wallenberg FoundationKnut & Alice Wallenberg Foundation [KAW2012.0101, KAW2017.0312]; Swedish Cancer Foundation [CAN2017/257]; University of QueenslandUniversity of Queensland

Available from: 2020-01-02 Created: 2020-01-02 Last updated: 2020-03-30Bibliographically approved

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Bivik Stadler, Caroline

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Medical Biotechnology (with a focus on Cell Biology (including Stem Cell Biology), Molecular Biology, Microbiology, Biochemistry or Biopharmacy)

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