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Morbidity and mortality in very old individuals with subsyndromal depression: an 8-year prospective study
Linköping University, Department of Clinical and Experimental Medicine, Division of Neuro and Inflammation Science. Linköping University, Faculty of Medicine and Health Sciences. Region Östergötland, Local Health Care Services in Central Östergötland, Psykiatriska kliniken inkl beroendekliniken.
Linköping University, Department of Clinical and Experimental Medicine, Division of Neuro and Inflammation Science. Linköping University, Faculty of Medicine and Health Sciences. Region Östergötland, Local Health Care Services in Central Östergötland, Department of Acute Internal Medicine and Geriatrics.ORCID iD: 0000-0002-6452-3930
Linköping University, Department of Clinical and Experimental Medicine, Division of Neuro and Inflammation Science. Linköping University, Faculty of Medicine and Health Sciences. Region Östergötland, Local Health Care Services in Central Östergötland, Department of Acute Internal Medicine and Geriatrics.
Linköping University, Department of Medical and Health Sciences, Division of Community Medicine. Linköping University, Faculty of Medicine and Health Sciences. Region Östergötland, Local Health Care Services in East Östergötland, Department of Advanced Home Care in Norrköping.
2019 (English)In: International psychogeriatrics, ISSN 1041-6102, E-ISSN 1741-203X, Vol. 31, no 11, p. 1569-1579, article id PII S1041610219001480Article in journal (Refereed) Published
Abstract [en]

Objectives: Both morbidity and mortality are elevated for individuals with subsyndromal depression (SSD) compared to non-depression (ND) in those of younger ages, but scientific studies are scarce for very old individuals. The aim of this study was therefore to compare the morbidity and mortality in very old individuals with SSD and ND. Design and setting: An 8-year prospective population-based study was undertaken on 85-year-old individuals in Sweden. Measurements: Data were collected from postal questionnaires and clinical assessments at baseline, after 1, 5, and 8 years. Depressive symptoms were measured with Geriatric Depression Scale and the results were classified into ND, SSD, and syndromal depression. Mortality was investigated using multivariable cox regressions, and variables of morbidity were investigated using linear mixed models. Results: Compared to ND, in people with SSD, mortality was elevated in the univariate regression, but this association vanished when controlling for relevant covariates. Morbidity was elevated with regard to basic activities of daily living (ADLs), instrumental ADLs, loneliness, self-perceived health, and depressive symptoms for individuals with SSD compared to ND, whereas cognitive speed, executive functions, and global cognitive function were not significantly impaired when adjusting for covariates. Conclusions: SSD among very old individuals is longitudinally associated with elevated morbidity but not mortality, when controlling for relevant covariates. Considering the high prevalence of SSD and the demographic development of increasing numbers of very old people, the findings highlight the need to develop clinical and societal strategies to prevent SSD and associated negative outcomes.

Place, publisher, year, edition, pages
CAMBRIDGE UNIV PRESS , 2019. Vol. 31, no 11, p. 1569-1579, article id PII S1041610219001480
Keywords [en]
Subthreshold depression; late life depression; elderly; loneliness; longitudinal; cognition
National Category
Geriatrics
Identifiers
URN: urn:nbn:se:liu:diva-163050DOI: 10.1017/S1041610219001480ISI: 000501416900006PubMedID: 31668146OAI: oai:DiVA.org:liu-163050DiVA, id: diva2:1384243
Note

Funding Agencies|Region Ostergotland, Sweden

Available from: 2020-01-09 Created: 2020-01-09 Last updated: 2020-02-06

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Ludvigsson, MikaelMarcusson, JanWressle, EwaMilberg, Anna
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Division of Neuro and Inflammation ScienceFaculty of Medicine and Health SciencesPsykiatriska kliniken inkl beroendeklinikenDepartment of Acute Internal Medicine and GeriatricsDivision of Community MedicineDepartment of Advanced Home Care in Norrköping
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