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Immune Biomarkers for Diagnosis and Treatment Monitoring of Tuberculosis: Current Developments and Future Prospects
Xiamen Univ Malaysia, Malaysia.
Xiamen Univ Malaysia, Malaysia; Xiamen Univ Malaysia, Malaysia.
Emory Vaccine Ctr, GA USA.
Univ Malaya, Malaysia.
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2019 (English)In: Frontiers in Microbiology, ISSN 1664-302X, E-ISSN 1664-302X, Vol. 10, article id 2789Article, review/survey (Refereed) Published
Abstract [en]

Tuberculosis (TB) treatment monitoring is paramount to clinical decision-making and the host biomarkers appears to play a significant role. The currently available diagnostic technology for TB detection is inadequate. Although GeneXpert detects total DNA present in the sample regardless live or dead bacilli present in clinical samples, all the commercial tests available thus far have low sensitivity. Humoral responses against Mycobacterium tuberculosis (Mtb) antigens are generally low, which precludes the use of serological tests for TB diagnosis, prognosis, and treatment monitoring. Mtb-specific CD4(+) T cells correlate with Mtb antigen/bacilli burden and hence might serve as good biomarkers for monitoring treatment progress. Omics-based techniques are capable of providing a more holistic picture for disease mechanisms and are more accurate in predicting TB disease outcomes. The current review aims to discuss some of the recent advances on TB biomarkers, particularly host biomarkers that have the potential to diagnose and differentiate active TB and LTBI as well as their use in disease prognosis and treatment monitoring.

Place, publisher, year, edition, pages
Frontiers Media S.A., 2019. Vol. 10, article id 2789
Keywords [en]
biomarkers; diagnostics; treatment monitoring; tuberculosis; HIV
National Category
Microbiology in the medical area
Identifiers
URN: urn:nbn:se:liu:diva-163106DOI: 10.3389/fmicb.2019.02789ISI: 000504978800001PubMedID: 31921004Scopus ID: 2-s2.0-85077356919OAI: oai:DiVA.org:liu-163106DiVA, id: diva2:1385075
Note

Funding Agencies|Xiamen University Malaysia Research Funding (XMUMRF) [XMUMRF/2018-C2/ILAB/0001]; Swedish Research CouncilSwedish Research Council; Swedish Physicians against AIDS Research Foundation; VINNMER for VinnovaVinnova; Linkoping University Hospital Research Fund; ALF Grants Region Ostergotland; FORSS

Available from: 2020-01-13 Created: 2020-01-13 Last updated: 2020-02-14Bibliographically approved

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