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Subjects with high fasting insulin also have higher postprandial GLP-1 and glucagon levels than controls with lower insulin
Linköping University, Department of Medical and Health Sciences. Linköping University, Faculty of Medicine and Health Sciences.
Linköping University, Department of Medical and Health Sciences. Linköping University, Faculty of Medicine and Health Sciences.
Linköping University, Department of Medical and Health Sciences. Linköping University, Faculty of Medicine and Health Sciences.
Linköping University, Department of Medical and Health Sciences. Linköping University, Faculty of Medicine and Health Sciences.
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2019 (English)In: Nutrition Research, ISSN 0271-5317, E-ISSN 1879-0739, Vol. 72, p. 111-120Article in journal (Refereed) Published
Abstract [en]

Little is known about postprandial release of serum ghrelin, glucagon, and glucagon-like peptide-1 (GLP-1) in relation with differing fasting insulin levels. We hypothesized that these hormones are affected by insulin resistance, and hence, we compared different postprandial responses of GLP-1, glucagon, and ghrelin in subjects with relatively high (RHI) or relatively low (RLI) fasting insulin levels. The trial was a randomized crossover study with 4 different meal conditions. Fourteen nonobese or obese, healthy, men and 14 women were randomly assigned to the order of supervised intake of a 750 kcal drink with the same protein contents but with 20 energy-percent (E%) or 55 E% from carbohydrates, and the remaining energy from fat. Participants were also randomized to consume the drinks as 1 large beverage or as five 150-kcal portions every 30 minutes. The 28 subjects were divided into 2 equally sized groups based on fasting insulin levels. Statistics were done with general linear mixed model. Fasting insulin levels were 3-fold higher in the group with RHI compared with the RLI group (RHI: 1004 +/- 510 pg/mL, RLI: 324 +/- 123 pg/mL, P amp;lt; .0005). Serum GLP-1 was highest in the RHI group after both single meals and after 5 drinks and following high- and low-carbohydrate meals (both P amp;lt;= .002), and this was the case also for glucagon levels (both P amp;lt;= .018), whereas ghrelin levels did not differ between groups. Thus, subjects with RHI displayed both higher postprandial serum GLP-1 and glucagon than the participants with RLI, suggesting that glucagon could play a role in the advent of dysglycemia by insulin resistance. (C) 2019 Elsevier Inc. All rights reserved.

Place, publisher, year, edition, pages
PERGAMON-ELSEVIER SCIENCE LTD , 2019. Vol. 72, p. 111-120
Keywords [en]
Carbohydrate content; Ghrelin; Glucagon; Glucagon-like peptide-1; Satiety; Meal distribution
National Category
Endocrinology and Diabetes
Identifiers
URN: urn:nbn:se:liu:diva-163259DOI: 10.1016/j.nutres.2019.10.009ISI: 000505272700010PubMedID: 31759769OAI: oai:DiVA.org:liu-163259DiVA, id: diva2:1390978
Note

Funding Agencies|County Council of Ostergotland; Linkoping University, Department of Medical and Health Sciences; Swedish Heart-Lung FoundationSwedish Heart-Lung Foundation; Gamla Tjanarinnor

Available from: 2020-02-03 Created: 2020-02-03 Last updated: 2020-04-30

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The full text will be freely available from 2020-10-27 15:08
Available from 2020-10-27 15:08

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Albinsson-Stenholm, ErinaBergsen, JohannesIngues, SimonVilhelmsson, NathalieGuldbrand, HansNyström, Fredrik H
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Department of Medical and Health SciencesFaculty of Medicine and Health Sciences"Primary Health Care in Motala"Division of Cardiovascular MedicinePrimary Health Care Center Cityhälsan Centrum, Norrköping
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