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Spinal signalling of C-fiber mediated pleasant touch in humans
Univ Liverpool, England; Liverpool John Moores Univ, England; Walton Ctr NHS Fdn Trust, England.
Walton Ctr NHS Fdn Trust, England.
Aintree Univ Hosp NHS Fdn Trust, England.
Linköping University, Faculty of Medicine and Health Sciences. Region Östergötland, Anaesthetics, Operations and Specialty Surgery Center, Department of Clinical Neurophysiology. Linköping University, Center for Medical Image Science and Visualization (CMIV). Linköping University, Department of Clinical and Experimental Medicine, Center for Social and Affective Neuroscience. Aintree Univ Hosp NHS Fdn Trust, England.
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2019 (English)In: eLIFE, E-ISSN 2050-084X, Vol. 8, article id e51642Article in journal (Refereed) Published
Abstract [en]

C-tactile afferents form a distinct channel that encodes pleasant tactile stimulation. Prevailing views indicate they project, as with other unmyelinated afferents, in lamina I-spinothalamic pathways. However, we found that spinothalamic ablation in humans, whilst profoundly impairing pain, temperature and itch, had no effect on pleasant touch perception. Only discriminative touch deficits were seen. These findings preclude privileged C-tactile-lamina I-spinothalamic projections and imply integrated hedonic and discriminative spinal processing from the body.

Place, publisher, year, edition, pages
ELIFE SCIENCES PUBLICATIONS LTD , 2019. Vol. 8, article id e51642
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Biophysics
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URN: urn:nbn:se:liu:diva-163474DOI: 10.7554/eLife.51642ISI: 000508133000001PubMedID: 31872799OAI: oai:DiVA.org:liu-163474DiVA, id: diva2:1393673
Note

Funding Agencies|Pain Relief Foundation

Available from: 2020-02-17 Created: 2020-02-17 Last updated: 2020-04-30

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Olausson, Håkan
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Faculty of Medicine and Health SciencesDepartment of Clinical NeurophysiologyCenter for Medical Image Science and Visualization (CMIV)Center for Social and Affective Neuroscience
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